The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aspartate Aminotransferase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 29: 5-aminolevulinate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
11 O18680 (/ISS) P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q54UX3 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q8T4G6 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
(1 more)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
5 O14092 (/IMP) O94069 (/IMP) P08680 (/IMP) P08680 (/IMP) P09950 (/IMP)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
4 P09950 (/IDA) P13195 (/IDA) P22557 (/IDA) Q63147 (/IDA)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
4 P08680 (/ISO) P08680 (/ISO) Q8VC19 (/ISO) Q8VC19 (/ISO)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
2 P08680 (/ISO) P08680 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q8VC19 (/ISO) Q8VC19 (/ISO)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
2 P08680 (/ISO) P08680 (/ISO)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
1 O94069 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P22557 (/IPI)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 O14092 (/ISM)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 Q63147 (/IDA)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 P22557 (/ISS)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 Q63147 (/IDA)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
1 P22557 (/ISS)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
8 P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
8 O18680 (/ISS) P22557 (/ISS) Q54UX3 (/ISS) Q63147 (/ISS) Q8T4G6 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
6 O14092 (/IMP) O94069 (/IMP) P08680 (/IMP) P08680 (/IMP) P09950 (/IMP) Q9YHT4 (/IMP)
Siroheme biosynthetic process GO:0019354
The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.
6 A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
5 P22557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
5 P22557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
3 P08680 (/IMP) P08680 (/IMP) Q9YHT4 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P13195 (/IEP) Q63147 (/IEP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P08680 (/ISO) P08680 (/ISO)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
2 P18080 (/TAS) P22557 (/TAS)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 P08680 (/IMP) P08680 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
2 P08680 (/IMP) P08680 (/IMP)
Response to cobalt ion GO:0032025
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.
2 P13195 (/IEP) Q63147 (/IEP)
Chitin-based cuticle development GO:0040003
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
2 O18680 (/IMP) Q8T4G6 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P13195 (/IEP) Q63147 (/IEP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P22557 (/IDA)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
1 P22557 (/NAS)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 P22557 (/ISS)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 Q63147 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 P13195 (/IEP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P13195 (/IEP)
Response to nickel cation GO:0010045
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus.
1 P13195 (/IEP)
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 Q63147 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P13195 (/IEP)
Hemoglobin metabolic process GO:0020027
The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
1 Q9YHT4 (/IGI)
Hemoglobin metabolic process GO:0020027
The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.
1 Q9YHT4 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
1 P22557 (/NAS)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P13195 (/IEP)
Oxygen homeostasis GO:0032364
A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.
1 P22557 (/NAS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P13195 (/IEP)
Response to gonadotropin GO:0034698
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
1 P13195 (/IEP)
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
1 Q9YHT4 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P13195 (/IEP)
Erythrocyte development GO:0048821
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
1 Q9YHT4 (/IMP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 P13195 (/IEP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 Q63147 (/IEP)
Response to platinum ion GO:0070541
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus.
1 P13195 (/IEP)
Response to fatty acid GO:0070542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q63147 (/IEP)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P13195 (/IEP)
Liver regeneration GO:0097421
The regrowth of lost or destroyed liver.
1 Q63147 (/IEP)
Response to benzene GO:1901423
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus.
1 Q63147 (/IEP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
8 P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 P08680 (/ISS) P08680 (/ISS) Q54UX3 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 O14092 (/HDA) P08680 (/HDA) P08680 (/HDA) P09950 (/HDA) Q8VC19 (/HDA) Q8VC19 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P08680 (/ISO) P08680 (/ISO) Q8VC19 (/ISO) Q8VC19 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P13195 (/IDA) P22557 (/IDA) Q63147 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 O14092 (/ISS) O18680 (/ISS) Q8T4G6 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q8VC19 (/ISO) Q8VC19 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P08680 (/ISO) P08680 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 P18080 (/TAS) P22557 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8VC19 (/ISO) Q8VC19 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P22557 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P09950 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P18080 (/TAS)
CATH-Gene3D is a Global Biodata Core Resource Learn more...