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CATH Superfamily 3.90.110.10

Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Malate dehydrogenase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malate dehydrogenase. [EC: 1.1.1.37]
(S)-malate + NAD(+) = oxaloacetate + NADH.
  • Also oxidizes some other 2-hydroxydicarboxylic acids.
 931 A0A045J3L7 A0A045J3L7 A0A045J3L7 A0A045J3L7 A0A045J3L7 A0A045J3L7 A0A045J3L7 A0A045J3L7 A0A045J3L7 A0A045J3L7
(921 more...)
Malate dehydrogenase (NADP(+)). [EC: 1.1.1.82]
(S)-malate + NADP(+) = oxaloacetate + NADPH.
  • Activated by light.
 10 C5YMV5 C5YMV5 O48902 P15719 P17606 P17606 P21528 P37229 P46489 Q8H1E2
Diiodophenylpyruvate reductase. [EC: 1.1.1.96]
3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4- hydroxyphenyl)pyruvate + NADH.
  • Substrates contain an aromatic ring with a pyruvate side chain.
  • The most active substrates are halogenated derivatives.
  • Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.
 4 P40925 P40925 V9HWF2 V9HWF2