The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Iron-sulfur cluster assembly scaffold protein IscU

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
368 O31270 (/IPI) O31270 (/IPI) O31270 (/IPI) O49627 (/IPI) O49627 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI)
(358 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
181 P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI) P0ACD4 (/IPI)
(171 more)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
181 P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA)
(171 more)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
181 P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA)
(171 more)
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
3 O49627 (/ISS) O49627 (/ISS) O81433 (/ISS)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
2 Q9VHK6 (/IDA) Q9VHK6 (/IDA)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q9H1K1 (/TAS)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q9H1K1 (/IDA)
Molecular adaptor activity GO:0060090
The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q9D7P6 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
183 P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA)
(173 more)
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
2 Q8LR34 (/IDA) Q8LR34 (/IDA)
[4Fe-4S] cluster assembly GO:0044572
The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster.
2 Q8LR34 (/IDA) Q8LR34 (/IDA)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
1 Q9H1K1 (/TAS)
Small molecule metabolic process GO:0044281
The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
1 Q9H1K1 (/TAS)
Positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958
Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.
1 Q9H1K1 (/IMP)
Positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958
Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.
1 Q9D7P6 (/ISO)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
1 Q9H1K1 (/IMP)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
1 Q9D7P6 (/ISO)
Negative regulation of iron ion import across plasma membrane GO:1904439
Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane.
1 Q9H1K1 (/IMP)
Negative regulation of iron ion import across plasma membrane GO:1904439
Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane.
1 Q9D7P6 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
187 A0A024RBI3 (/IDA) A0A024RBI3 (/IDA) A0A024RBI3 (/IDA) A0A024RBI3 (/IDA) A0A024RBI3 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA) P0ACD4 (/IDA)
(177 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 O49627 (/IDA) O49627 (/IDA) O81433 (/IDA) Q9D7P6 (/IDA) Q9H1K1 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q8LR34 (/IDA) Q8LR34 (/IDA)
L-cysteine desulfurase complex GO:1990221
A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer.
2 Q9VHK6 (/IDA) Q9VHK6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9H1K1 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9H1K1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9D7P6 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D7P6 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D7P6 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9H1K1 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9D7P6 (/ISO)
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