Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.

Any process that activates or increases the rate or extent of B cell proliferation.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

Any process that modulates the frequency, rate or extent of B cell differentiation.

Any process that activates or increases the frequency, rate or extent of B cell activation.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

Any series of molecular signals generated as a consequence of binding to toll-like receptor 9.

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.

The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.

Any process that activates or increases the frequency, rate, or extent of chemokine production.

Any process that activates or increases the frequency, rate, or extent of chemokine production.

Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.

Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.

The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

Any series of molecular signals generated as a consequence of binding to toll-like receptor 7.

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.

Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.

Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.

Any process that activates or increases the rate or extent of B cell proliferation.

Any process that activates or increases the rate or extent of B cell proliferation.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.

Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.

Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.

Any process that activates or increases the frequency, rate, or extent of interferon-beta production.

Any process that activates or increases the frequency, rate, or extent of interferon-beta production.

Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.

Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.

Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.

Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.

Any series of molecular signals generated as a consequence of binding to toll-like receptor 7.

Any series of molecular signals generated as a consequence of binding to toll-like receptor 8.

Any series of molecular signals generated as a consequence of binding to toll-like receptor 8.

Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

Any process that activates or increases the frequency, rate or extent of JUN kinase activity.

Any process that activates or increases the frequency, rate or extent of JUN kinase activity.

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

Any process that modulates the frequency, rate or extent of B cell differentiation.

Any process that modulates the frequency, rate or extent of B cell differentiation.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.

Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.

Any process that modulates the frequency, rate or extent of B cell activation.

Any process that activates or increases the frequency, rate or extent of B cell activation.

Any process that activates or increases the frequency, rate or extent of B cell activation.

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.

Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.

Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus.

Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.

Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion.

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion.

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

A vacuole to which materials ingested by endocytosis are delivered.

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

The lipid bilayer surrounding an endosome.

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The lipid bilayer surrounding the endoplasmic reticulum.

The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

A vacuole to which materials ingested by endocytosis are delivered.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.

Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

The region of the plasma membrane located at the apical end of the cell.

The region of the plasma membrane located at the apical end of the cell.

An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.

An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.

An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.

A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.