The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Leucine rich repeat containing 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
22 A8BBF0 (/IPI) P0C192 (/IPI) Q8C031 (/IPI) Q8C031 (/IPI) Q99PH1 (/IPI) Q9HBW1 (/IPI) Q9HBW1 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI)
(12 more)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
15 Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI) Q9HCJ2 (/IPI)
(5 more)
Cell-cell adhesion mediator activity GO:0098632
The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.
15 Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI)
(5 more)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 Q8C031 (/ISO) Q8C031 (/ISO)
Cell-cell adhesion mediator activity GO:0098632
The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.
2 Q8C031 (/ISO) Q8C031 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P0C192 (/IPI)
Fibroblast growth factor receptor binding GO:0005104
Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR).
1 Q6RKD8 (/IPI)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
1 Q9NZU1 (/NAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 A8BBF0 (/IDA)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
15 Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA)
(5 more)
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
15 Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI) Q9HCJ2 (/IGI)
(5 more)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
4 Q9NT99 (/ISS) Q9NT99 (/ISS) Q9NT99 (/ISS) Q9NT99 (/ISS)
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
4 P0CC10 (/IDA) Q45R42 (/IDA) Q8C031 (/IDA) Q8C031 (/IDA)
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
4 P0CC10 (/IMP) Q45R42 (/IMP) Q8C031 (/IMP) Q8C031 (/IMP)
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
4 P0C192 (/ISO) Q8C031 (/ISO) Q8C031 (/ISO) Q99PH1 (/ISO)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
3 Q8C031 (/IMP) Q8C031 (/IMP) Q99PH1 (/IMP)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
2 Q8C031 (/ISO) Q8C031 (/ISO)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
2 Q8C031 (/ISS) Q8C031 (/ISS)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
2 P0C192 (/IDA) Q6RKD8 (/IDA)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q6RKD8 (/IMP)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q9NZU1 (/ISS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q9NZU1 (/TAS)
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
1 Q6RKD8 (/IMP)
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
1 Q9NZU1 (/ISS)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 Q99PH1 (/IDA)
Postsynaptic density protein 95 clustering GO:0097119
The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins.
1 Q99PH1 (/IDA)
Regulation of postsynaptic density assembly GO:0099151
Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.
1 P0CC10 (/IDA)
Regulation of postsynaptic density assembly GO:0099151
Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.
1 P0CC10 (/IMP)
Regulation of postsynaptic density assembly GO:0099151
Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.
1 P0C192 (/ISO)
Excitatory synapse assembly GO:1904861
The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse.
1 Q99PH1 (/IMP)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
1 P0CC10 (/IDA)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
1 P0CC10 (/IMP)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
1 P0C192 (/ISO)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q6RKD8 (/IMP)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9NZU1 (/ISS)

There are 33 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
15 Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA) Q9HCJ2 (/HDA)
(5 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
15 Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA) Q9HCJ2 (/IDA)
(5 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
15 Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS) Q9HCJ2 (/NAS)
(5 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 Q9NT99 (/TAS) Q9NT99 (/TAS) Q9NT99 (/TAS) Q9NT99 (/TAS) Q9NZU1 (/TAS)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P0CC10 (/IDA) Q45R42 (/IDA) Q8C031 (/IDA) Q8C031 (/IDA) Q99PH1 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 P0CC10 (/IDA) Q45R42 (/IDA) Q8C031 (/IDA) Q8C031 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 P0CC10 (/IMP) Q8C031 (/IMP) Q8C031 (/IMP) Q99PH1 (/IMP)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
3 Q8C031 (/IDA) Q8C031 (/IDA) Q99PH1 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8C031 (/ISO) Q8C031 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8C031 (/ISS) Q8C031 (/ISS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 P0C192 (/ISO) Q99PH1 (/ISO)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P0C192 (/ISO) Q99PH1 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q6RKD8 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6RKD8 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9NZU1 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9NZU1 (/NAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q6RKD8 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q9NZU1 (/ISS)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 Q9NZU1 (/NAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q6RKD8 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q9NZU1 (/ISS)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
1 Q6RKD8 (/IDA)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
1 Q9NZU1 (/ISS)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 Q99PH1 (/IDA)
Cerebellar mossy fiber GO:0044300
An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \mossy\ appearance in Golgi stained preparations.
1 P0C192 (/IDA)
Neuron projection terminus GO:0044306
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
1 Q6RKD8 (/IDA)
Neuron projection terminus GO:0044306
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
1 Q9NZU1 (/ISS)
Neuron spine GO:0044309
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
1 Q99PH1 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q99PH1 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 Q99PH1 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q6RKD8 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q9NZU1 (/ISS)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
1 Q99PH1 (/IDA)
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