The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
PPM-type phosphatase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Protein phosphatase 2C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
12 A0A1D8PRZ8 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P34221 (/IPI) P34221 (/IPI) P34221 (/IPI) P34221 (/IPI) P34221 (/IPI) P34221 (/IPI) P39966 (/IPI) P39966 (/IPI) P39966 (/IPI) P39966 (/IPI)
(1 more)
MAP kinase serine/threonine phosphatase activity GO:1990439
Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate.
6 P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) Q09173 (/IDA)
Magnesium-dependent protein serine/threonine phosphatase activity GO:0004724
Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium.
5 P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2 Q9VZS1 (/ISS) Q9W0Q0 (/ISS)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
2 Q09172 (/IMP) Q09173 (/IMP)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
2 Q381U4 (/ISM) Q381U4 (/ISM)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P49596 (/IPI)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
12 A0A1D8PRZ8 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA)
(2 more)
Regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079
Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
11 P34221 (/IMP) P34221 (/IMP) P34221 (/IMP) P34221 (/IMP) P34221 (/IMP) P34221 (/IMP) P39966 (/IMP) P39966 (/IMP) P39966 (/IMP) P39966 (/IMP)
(1 more)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
11 P34221 (/IGI) P34221 (/IGI) P34221 (/IGI) P34221 (/IGI) P34221 (/IGI) P34221 (/IGI) P39966 (/IGI) P39966 (/IGI) P39966 (/IGI) P39966 (/IGI)
(1 more)
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
5 P39966 (/IGI) P39966 (/IGI) P39966 (/IGI) P39966 (/IGI) P39966 (/IGI)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
5 P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
5 P39966 (/IMP) P39966 (/IMP) P39966 (/IMP) P39966 (/IMP) P39966 (/IMP)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
5 P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA)
Negative regulation of endoplasmic reticulum unfolded protein response GO:1900102
Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
5 P39966 (/IMP) P39966 (/IMP) P39966 (/IMP) P39966 (/IMP) P39966 (/IMP)
Negative regulation of endoplasmic reticulum unfolded protein response GO:1900102
Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
5 P39966 (/IPI) P39966 (/IPI) P39966 (/IPI) P39966 (/IPI) P39966 (/IPI)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
2 Q9VZS1 (/ISS) Q9W0Q0 (/ISS)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
2 Q381U4 (/ISM) Q381U4 (/ISM)
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
2 Q09173 (/IMP) Q4WTH5 (/IMP)
Inactivation of MAPK activity involved in osmosensory signaling pathway GO:0000173
Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing.
1 Q4WTH5 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 Q4WTH5 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q4WTH5 (/IMP)
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
1 P49596 (/IGI)
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
1 P49596 (/IMP)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
1 Q09172 (/ISO)
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
1 Q4WTH5 (/IMP)
Negative regulation of stress-activated MAPK cascade GO:0032873
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
1 Q09173 (/IMP)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 P49596 (/IMP)
Cellular response to carbon dioxide GO:0071244
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
1 A0A1D8PRZ8 (/IMP)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
1 Q09173 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
13 P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P39966 (/HDA) P39966 (/HDA) P39966 (/HDA) P39966 (/HDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
12 A0A1D8PRZ8 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
11 P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P34221 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA) P39966 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P34221 (/HDA) P39966 (/HDA) P39966 (/HDA) P39966 (/HDA) P39966 (/HDA)
(1 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q381U4 (/IDA) Q381U4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q09172 (/HDA) Q09173 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 A0A1D8PRZ8 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q4Q5B1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9VZS1 (/ISS)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
1 P49596 (/IDA)
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