The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: Tartrate-resistant acid phosphatase type 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
4 O97860 (/ISS) P09889 (/ISS) P29288 (/ISS) Q05117 (/ISS)
Ferric iron binding GO:0008199
Interacting selectively and non-covalently with ferric iron, Fe(III).
4 O97860 (/ISS) P09889 (/ISS) P29288 (/ISS) Q05117 (/ISS)
Acid phosphatase activity GO:0003993
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
3 P13686 (/TAS) P13686 (/TAS) P29288 (/TAS)
Acid phosphatase activity GO:0003993
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
2 P29288 (/IDA) Q05117 (/IDA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
2 P13686 (/IDA) P13686 (/IDA)
Ferric iron binding GO:0008199
Interacting selectively and non-covalently with ferric iron, Fe(III).
2 P13686 (/IDA) P13686 (/IDA)
Acid phosphatase activity GO:0003993
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
1 Q05117 (/IMP)
Hydrolase activity GO:0016787
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
1 P29288 (/IDA)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Riboflavin metabolic process GO:0006771
The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
2 P13686 (/TAS) P13686 (/TAS)
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 P29288 (/IEP)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
1 P29288 (/IDA)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 P29288 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P29288 (/IEP)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 Q05117 (/IDA)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 P29288 (/IEP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P29288 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q05117 (/IMP)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
1 Q05117 (/IMP)
Negative regulation of interleukin-12 production GO:0032695
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
1 Q05117 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 Q05117 (/IMP)
Negative regulation of superoxide anion generation GO:0032929
Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell.
1 Q05117 (/IMP)
Multicellular organismal response to stress GO:0033555
Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
1 P29288 (/IEP)
Response to L-ascorbic acid GO:0033591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus.
1 P29288 (/IEP)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 Q05117 (/IDA)
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q05117 (/IMP)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
1 P29288 (/IEP)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
1 Q05117 (/IMP)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
1 P29288 (/TAS)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 Q05117 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q05117 (/IMP)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
1 Q05117 (/IMP)
Response to cholesterol GO:0070723
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
1 P29288 (/IEP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P13686 (/TAS) P13686 (/TAS) P29288 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P13686 (/TAS) P13686 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P29288 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q05117 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q05117 (/IMP)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 P29288 (/TAS)
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