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CATH Superfamily 3.60.20.10

Aminohydrolase, N-terminal nucleophile (Ntn) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: ATP-dependent protease subunit HslV

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
HslU--HslV peptidase. [EC: 3.4.25.2]
ATP-dependent cleavage of peptide bonds with broad specificity.
  • The HslU subunit of the HslU--HslV complex functions as an ATP dependent 'unfoldase'.
  • The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.
  • HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
  • Belongs to peptidase family T1.
 32808 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5 A0A023Z5Z5
(32798 more...)