The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: MBL fold metallo-hydrolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hydroxyacylglutathione hydrolase activity GO:0004416
Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
23 P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA)
(13 more)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
8 Q9KSI6 (/ISS) Q9KSI6 (/ISS) Q9KSI6 (/ISS) Q9KSI6 (/ISS) Q9KSI6 (/ISS) Q9KSI6 (/ISS) Q9KSI6 (/ISS) Q9KSI6 (/ISS)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
23 P75849 (/IMP) P75849 (/IMP) P75849 (/IMP) P75849 (/IMP) P75849 (/IMP) P75849 (/IMP) P75849 (/IMP) P75849 (/IMP) P75849 (/IMP) P75849 (/IMP)
(13 more)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
23 P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA) P75849 (/IDA)
(13 more)
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