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CATH Superfamily 3.60.130.10

Clavaminate synthase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Clavaminate synthase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Alpha-ketoglutarate-dependent L-arginine hydroxyla...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-asparagine oxygenase. [EC: 1.14.11.39]
L-asparagine + 2-oxoglutarate + O(2) = (2S,3S)-3-hydroxyasparagine + succinate + CO(2).
  • The enzyme is only able to hydroxylate free L-asparagine.
  • It is not active toward D-asparagine.
  • The beta-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non- ribosomally synthesized acidic lipopeptide lactone.
  • Formerly EC 1.14.11.n1.
 36 A0A1H2BCA2 A0A1H2BCA2 A0A1H2BCA2 A0A1H2BCA2 A0A1H2BCA2 A0A1H2BCA2 A0A2P7ZFY3 A0A2P7ZFY3 A0A2P7ZFY3 A0A2P7ZFY3
(26 more...)
L-arginine hydroxylase. [EC: 1.14.11.41]
L-arginine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-arginine + succinate + CO(2).
  • The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin.
  • It differs from EC 1.14.20.7, because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine.
 2 C7Q942 Q6WZB0
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