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CATH Superfamily 3.60.120.10

Anthranilate synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Anthranilate synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Aminodeoxychorismate synthase component I

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-amino-4-deoxychorismate synthase. [EC: 2.6.1.86]
(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine.
  • The reaction occurs in the reverse direction to that shown above.
  • In contrast to most anthranilate-synthase I (ASI) homologs, this enzyme is not inhibited by tryptophan.
  • In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumor antibiotic C-1027.
  • In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity.
 4 A0A0U3LTB0 A0A0U3LTB0 Q8GMH4 Q8GMH4
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