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CATH Superfamily 3.60.10.10

Endonuclease/exonuclease/phosphatase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Endonuclease/exonuclease/phosphatase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 39: 72 kDa inositol polyphosphate 5-phosphatase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoinositide 5-phosphatase. [EC: 3.1.3.36]
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate.
  • These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4).
  • They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed.
  • They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo.
  • All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.
 8 A0FI79 A0FI79 K7B557 K7B557 Q9JII1 Q9NRR6 Q9VTW2 Q9WVR1
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