The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Endonuclease/exonuclease/phosphatase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: CCR4-NOT transcription complex subunit 6 like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
29 Q8IMX1 (/IPI) Q8VEG6 (/IPI) Q96LI5 (/IPI) Q96LI5 (/IPI) Q96LI5 (/IPI) Q96LI5 (/IPI) Q96LI5 (/IPI) Q96LI5 (/IPI) Q96LI5 (/IPI) Q96LI5 (/IPI)
(19 more)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
27 Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS)
(17 more)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
10 Q7K112 (/IDA) Q8IMX0 (/IDA) Q8IMX1 (/IDA) Q8MTZ5 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9VCB6 (/IDA)
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
5 Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA)
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
5 Q5BJ41 (/ISS) Q6AXU9 (/ISS) Q6AXU9 (/ISS) Q8K3P5 (/ISS) Q8K3P5 (/ISS)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
5 Q5BJ41 (/ISS) Q6AXU9 (/ISS) Q6AXU9 (/ISS) Q8K3P5 (/ISS) Q8K3P5 (/ISS)
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
2 Q8K3P5 (/ISO) Q8K3P5 (/ISO)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
2 Q8K3P5 (/ISO) Q8K3P5 (/ISO)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
1 Q8VEG6 (/IMP)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
28 Q8VEG6 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP)
(18 more)
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
27 Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS)
(17 more)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
27 Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS)
(17 more)
Positive regulation of cytoplasmic mRNA processing body assembly GO:0010606
Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
27 Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP) Q96LI5 (/IMP)
(17 more)
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
11 Q7K112 (/IMP) Q8IMX0 (/IMP) Q8IMX1 (/IMP) Q8MTZ5 (/IMP) Q9U1P4 (/IMP) Q9ULM6 (/IMP) Q9ULM6 (/IMP) Q9ULM6 (/IMP) Q9ULM6 (/IMP) Q9ULM6 (/IMP)
(1 more)
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
5 Q5BJ41 (/ISS) Q6AXU9 (/ISS) Q6AXU9 (/ISS) Q8K3P5 (/ISS) Q8K3P5 (/ISS)
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
5 Q7K112 (/IDA) Q8IMX0 (/IDA) Q8IMX1 (/IDA) Q8MTZ5 (/IDA) Q9VCB6 (/IDA)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
5 Q7K112 (/IDA) Q8IMX0 (/IDA) Q8IMX1 (/IDA) Q8MTZ5 (/IDA) Q9VCB6 (/IDA)
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
5 Q9ULM6 (/TAS) Q9ULM6 (/TAS) Q9ULM6 (/TAS) Q9ULM6 (/TAS) Q9ULM6 (/TAS)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
5 Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
5 Q5BJ41 (/ISS) Q6AXU9 (/ISS) Q6AXU9 (/ISS) Q8K3P5 (/ISS) Q8K3P5 (/ISS)
Female germ-line stem cell asymmetric division GO:0048132
The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.
5 Q7K112 (/IMP) Q8IMX0 (/IMP) Q8IMX1 (/IMP) Q8MTZ5 (/IMP) Q9VCB6 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
5 Q7K112 (/IMP) Q8IMX0 (/IMP) Q8IMX1 (/IMP) Q8MTZ5 (/IMP) Q9VCB6 (/IMP)
Nuclear-transcribed mRNA catabolic process, no-go decay GO:0070966
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.
5 Q9ULM6 (/IMP) Q9ULM6 (/IMP) Q9ULM6 (/IMP) Q9ULM6 (/IMP) Q9ULM6 (/IMP)
Nuclear-transcribed mRNA catabolic process, no-go decay GO:0070966
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.
5 Q5BJ41 (/ISS) Q6AXU9 (/ISS) Q6AXU9 (/ISS) Q8K3P5 (/ISS) Q8K3P5 (/ISS)
Positive regulation of nuclear receptor transcription coactivator activity GO:2000327
Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity.
5 Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA) Q9ULM6 (/IDA)
Positive regulation of nuclear receptor transcription coactivator activity GO:2000327
Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity.
5 Q5BJ41 (/ISS) Q6AXU9 (/ISS) Q6AXU9 (/ISS) Q8K3P5 (/ISS) Q8K3P5 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
3 Q8K3P5 (/ISO) Q8K3P5 (/ISO) Q8VEG6 (/ISO)
Positive regulation of cytoplasmic mRNA processing body assembly GO:0010606
Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
3 Q8K3P5 (/ISO) Q8K3P5 (/ISO) Q8VEG6 (/ISO)
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
2 Q8K3P5 (/ISO) Q8K3P5 (/ISO)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
2 Q8K3P5 (/ISO) Q8K3P5 (/ISO)
Nuclear-transcribed mRNA catabolic process, no-go decay GO:0070966
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation.
2 Q8K3P5 (/ISO) Q8K3P5 (/ISO)
Positive regulation of nuclear receptor transcription coactivator activity GO:2000327
Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity.
2 Q8K3P5 (/ISO) Q8K3P5 (/ISO)
Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288
A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
1 Q8VEG6 (/IMP)
Positive regulation of cytoplasmic mRNA processing body assembly GO:0010606
Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
1 Q8VEG6 (/ISS)
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
1 Q8VEG6 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
33 Q7K112 (/IDA) Q8IMX0 (/IDA) Q8IMX1 (/IDA) Q8MTZ5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA)
(23 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
31 H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) H0Y9Z5 (/IDA) Q96LI5 (/IDA)
(21 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
29 Q7K112 (/IDA) Q8IMX0 (/IDA) Q8IMX1 (/IDA) Q8MTZ5 (/IDA) Q8VEG6 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA)
(19 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
27 Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS) Q96LI5 (/TAS)
(17 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
22 Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA) Q96LI5 (/IDA)
(12 more)
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
11 A2BHJ4 (/ISS) Q5BJ41 (/ISS) Q5XH73 (/ISS) Q5XH73 (/ISS) Q6AXU9 (/ISS) Q6AXU9 (/ISS) Q6IR85 (/ISS) Q6IR85 (/ISS) Q8K3P5 (/ISS) Q8K3P5 (/ISS)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A2BHJ4 (/ISS) Q5XH73 (/ISS) Q5XH73 (/ISS) Q6IR85 (/ISS) Q6IR85 (/ISS) Q8VEG6 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A2BHJ4 (/ISS) Q5XH73 (/ISS) Q5XH73 (/ISS) Q6IR85 (/ISS) Q6IR85 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q7K112 (/HDA) Q8IMX0 (/HDA) Q8IMX1 (/HDA) Q8MTZ5 (/HDA) Q9VCB6 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 Q9ULM6 (/HDA) Q9ULM6 (/HDA) Q9ULM6 (/HDA) Q9ULM6 (/HDA) Q9ULM6 (/HDA)
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
3 Q8K3P5 (/ISO) Q8K3P5 (/ISO) Q8VEG6 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8VEG6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8VEG6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8VEG6 (/ISO)
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