View in Gene3D

CATH Superfamily 3.60.10.10

Endonuclease/exonuclease/phosphatase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Endonuclease/exonuclease/phosphatase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 14: Type I inositol polyphosphate 5-phosphatase 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoinositide 5-phosphatase. [EC: 3.1.3.36]
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate.
  • These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4).
  • They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed.
  • They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo.
  • All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.
 4 A0A178WAF8 A0A178WAF8 Q8H0Z6 Q8H0Z6
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase. [EC: 3.1.3.86]
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
  • This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways.
  • The enzyme also shows activity toward PtdIns(1,3,4,5)P(4).
  • The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
  • Formerly EC 3.1.3.n1.
 4 A0A178WAF8 A0A178WAF8 Q8H0Z6 Q8H0Z6
Inositol-polyphosphate 5-phosphatase. [EC: 3.1.3.56]
(1) D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4- bisphosphate + phosphate. (2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
  • This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36 by its inability to dephosphorylate inositol lipids.
 1 Q84MA2
CATH-Gene3D is a Global Biodata Core Resource Learn more...