The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Iron/manganese superoxide dismutase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Superoxide dismutase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
19 A0A1D8PQH5 (/IDA) A0A1D8PQH5 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA)
(9 more)
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
2 Q00637 (/ISS) Q55BJ9 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9UQX0 (/IPI) Q9UQX0 (/IPI)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
2 Q9UQX0 (/IDA) Q9UQX0 (/IDA)
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
1 Q9SM64 (/NAS)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 O81235 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P09233 (/TAS)
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
1 Q00637 (/NAS)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 P09233 (/TAS)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
1 O81235 (/IDA)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
15 P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP)
(5 more)
Age-dependent response to oxidative stress involved in chronological cell aging GO:0001324
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.
14 P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP)
(4 more)
Replicative cell aging GO:0001302
The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
12 P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP)
(2 more)
Age-dependent response to reactive oxygen species involved in chronological cell aging GO:0001320
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.
12 P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP) P00447 (/IMP)
(2 more)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
3 P41978 (/IEP) P41979 (/IEP) P41980 (/IEP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
3 P41978 (/IEP) P41979 (/IEP) P41980 (/IEP)
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
3 G5EAY6 (/IEP) G5EAY6 (/IEP) G5EAY6 (/IEP)
Floral organ abscission GO:0010227
The controlled shedding of floral organs.
2 Q9LYK8 (/IEP) Q9LYK8 (/IEP)
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
2 Q9UQX0 (/IMP) Q9UQX0 (/IMP)
Cellular response to lithium ion GO:0071285
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
2 Q5A8Z4 (/IMP) Q5A8Z4 (/IMP)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
2 Q5A8Z4 (/ISS) Q5A8Z4 (/ISS)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 P09233 (/IEP)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 P09233 (/TAS)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q00637 (/IMP)
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
1 Q55BJ9 (/ISS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P09233 (/TAS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q00637 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q00637 (/TAS)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 P09233 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 P09233 (/IDA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 O81235 (/IEP)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
1 O81235 (/IMP)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 O81235 (/IEP)
Regulation of metabolic process GO:0019222
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
1 Q00637 (/IMP)
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
1 Q00637 (/ISS)
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
1 Q9SM64 (/NAS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q6FV67 (/IMP)
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
1 Q00637 (/IMP)
Paracrine signaling GO:0038001
The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.
1 Q00637 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 O81235 (/IEP)
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 Q00637 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P09233 (/TAS)
Regulation of autophagy of mitochondrion GO:1903146
Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process.
1 Q00637 (/IGI)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
18 O81235 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA)
(8 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
14 P00447 (/HDA) P00447 (/HDA) P00447 (/HDA) P00447 (/HDA) P00447 (/HDA) P00447 (/HDA) P00447 (/HDA) P00447 (/HDA) P00447 (/HDA) P00447 (/HDA)
(4 more)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
14 P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA) P00447 (/IDA)
(4 more)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q9UQX0 (/ISO) Q9UQX0 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q00637 (/ISS) Q9SM64 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A0A1D8PQH5 (/IGI) A0A1D8PQH5 (/IGI)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q55BJ9 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P09233 (/TAS)