CATH Superfamily 3.50.50.80
Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1
".
FunFam 2: SUMO-activating enzyme subunit 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 23 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
|
8 | Q28GH3 (/ISS) Q54L40 (/ISS) Q642Q1 (/ISS) Q642Q1 (/ISS) Q7SXG4 (/ISS) Q7ZY60 (/ISS) Q9SJT1 (/ISS) Q9Z1F9 (/ISS) |
|
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
|
5 | O42939 (/IDA) Q9SJT1 (/IDA) Q9UBT2 (/IDA) Q9UBT2 (/IDA) Q9Z1F9 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q9SJT1 (/IPI) Q9UBT2 (/IPI) Q9UBT2 (/IPI) Q9Z1F9 (/IPI) |
|
Ubiquitin activating enzyme binding GO:0033134
Interacting selectively and non-covalently with a ubiquitin activating enzyme, any of the E1 proteins.
|
3 | Q7KJV6 (/IPI) Q7KUA4 (/IPI) Q9VSD9 (/IPI) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
2 | Q9UBT2 (/IMP) Q9UBT2 (/IMP) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | Q9UBT2 (/IMP) Q9UBT2 (/IMP) |
|
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
2 | Q9UBT2 (/TAS) Q9UBT2 (/TAS) |
|
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
|
2 | Q5BAI0 (/IMP) Q5BAI0 (/IMP) |
|
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
|
2 | Q9UBT2 (/TAS) Q9UBT2 (/TAS) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
2 | Q9UBT2 (/IPI) Q9UBT2 (/IPI) |
|
Small protein activating enzyme binding GO:0044388
Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.
|
2 | Q9UBT2 (/IPI) Q9UBT2 (/IPI) |
|
Ubiquitin-like protein conjugating enzyme binding GO:0044390
Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme.
|
2 | Q9UBT2 (/IPI) Q9UBT2 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q9UBT2 (/IMP) Q9UBT2 (/IMP) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q9UBT2 (/IPI) Q9UBT2 (/IPI) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | Q9Z1F9 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q9Z1F9 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q9Z1F9 (/IPI) |
|
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
|
1 | Q9Z1F9 (/ISO) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
1 | Q9Z1F9 (/ISO) |
|
Small protein activating enzyme binding GO:0044388
Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.
|
1 | Q9Z1F9 (/ISO) |
|
Ubiquitin-like protein conjugating enzyme binding GO:0044390
Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme.
|
1 | Q9Z1F9 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q9Z1F9 (/ISO) |
|
SUMO conjugating enzyme activity GO:0061656
Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.
|
1 | O42939 (/EXP) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
8 | Q28GH3 (/ISS) Q54L40 (/ISS) Q642Q1 (/ISS) Q642Q1 (/ISS) Q7SXG4 (/ISS) Q7ZY60 (/ISS) Q9SJT1 (/ISS) Q9Z1F9 (/ISS) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
7 | Q5BAI0 (/IMP) Q5BAI0 (/IMP) Q7KJV6 (/IMP) Q7KUA4 (/IMP) Q9UBT2 (/IMP) Q9UBT2 (/IMP) Q9VSD9 (/IMP) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
4 | O42939 (/IDA) Q9SJT1 (/IDA) Q9UBT2 (/IDA) Q9UBT2 (/IDA) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
3 | Q7KJV6 (/IDA) Q7KUA4 (/IDA) Q9VSD9 (/IDA) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
2 | Q9UBT2 (/TAS) Q9UBT2 (/TAS) |
|
Positive regulation of antimicrobial peptide production GO:0002225
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
|
1 | Q7KUA4 (/IMP) |
|
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
|
1 | Q9SJT1 (/IMP) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
1 | O42939 (/EXP) |
|
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
|
1 | Q9Z1F9 (/ISO) |
|
Positive regulation of Toll signaling pathway GO:0045752
Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway.
|
1 | Q7KUA4 (/IMP) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
|
7 | Q28GH3 (/ISS) Q54L40 (/ISS) Q642Q1 (/ISS) Q642Q1 (/ISS) Q7SXG4 (/ISS) Q7ZY60 (/ISS) Q9Z1F9 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q7KJV6 (/IDA) Q7KUA4 (/IDA) Q9SJT1 (/IDA) Q9VSD9 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q7KJV6 (/IDA) Q7KUA4 (/IDA) Q9VSD9 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q9UBT2 (/IDA) Q9UBT2 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q9UBT2 (/TAS) Q9UBT2 (/TAS) |
|
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
|
2 | Q9UBT2 (/IDA) Q9UBT2 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O42939 (/HDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9Z1F9 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9SJT1 (/IDA) |
|
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
|
1 | Q9SJT1 (/IDA) |
|
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
|
1 | Q9Z1F9 (/ISO) |
|
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
|
1 | O42939 (/TAS) |