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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 88: 3-phenylpropionate/cinnamic acid dioxygenase ferre...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ferredoxin--NAD(+) reductase. [EC: 1.18.1.3]
Reduced ferredoxin + NAD(+) = oxidized ferredoxin + NADH.
  • The reaction is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems.
  • some anaerobic bacteria have a 2[4Fe-4S] ferredoxin, which transfers two electrons.
 2506 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6
(2496 more...)
Putidaredoxin--NAD(+) reductase. [EC: 1.18.1.5]
Reduced putidaredoxin + NAD(+) = oxidized putidaredoxin + NADH.
  • The enzyme from Pseudomonas putida reduces putidaredoxin.
  • It contains a [2Fe-2S] cluster.
  • Involved in the camphor monooxygenase system (see EC 1.14.15.1).
 4 M5AXR7 M5AXR7 P16640 P16640
Rubredoxin--NAD(+) reductase. [EC: 1.18.1.1]
2 reduced rubredoxin + NAD(+) + H(+) = 2 oxidized rubredoxin + NADH.
  • The enzyme from Clostridium acetobutylicum reduces rubredoxin, ferricyanide and dichlorophenolindophenol, but not ferredoxin or flavodoxin.
  • The reaction does not occur when NADPH is substituted for NADH.
  • Formerly EC 1.6.7.2.
 2 P17052 Q9L4M8
Ferredoxin--NADP(+) reductase. [EC: 1.18.1.2]
2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH.
  • In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe- 2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin.
  • Formerly EC 1.6.7.1 and EC 1.6.99.4.
 1 D5IGG6
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