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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 644: H(2):CoB-CoM heterodisulfide,ferredoxin reductase ...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
H(2):CoB-CoM heterodisulfide,ferredoxin reductase. [EC: 1.8.98.5]
2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H(+) = 2 H(2) + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB.
  • This enzyme complex is found in H(2)-oxidizing CO(2)-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus.
  • It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase.
  • Electron pairs donated by the hydrogenase are transfered via its Delta subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide.
  • The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase.
  • Cf. EC 1.8.7.3, EC 1.8.98.4, and EC 1.8.98.1.
 1 Q50756
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