View in Gene3D

CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 25: Dihydrolipoyl dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydrolipoyl dehydrogenase. [EC: 1.8.1.4]
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
  • A component of the multienzyme 2-oxo-acid dehydrogenase complexes.
  • In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.
  • It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.
  • Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.
  • It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.
  • Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.
  • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
  • Formerly EC 1.6.4.3.
 30 A0A024R713 A0A024R713 A0A024R713 A0A178W162 A0A178W162 A0A2J8QXX9 A0A2J8QXX9 A0A2J8QXX9 G7P2G2 G7P2G2
(20 more...)
Leghemoglobin reductase. [EC: 1.6.2.6]
NAD(P)H + 2 ferrileghemoglobin = NAD(P)(+) + 2 ferroleghemoglobin.
    		 2 Q41219 Q9SPB1
    CATH-Gene3D is a Global Biodata Core Resource Learn more...