CATH Superfamily 3.50.50.60

FunFam 144: Dimethylaniline monooxygenase [N-oxide-forming]

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

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EC Term	Annotations	Evidence
Flavin-containing monooxygenase. [EC: 1.14.13.8] N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O. A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines. Is distinct from other monooxygenases in that the enzyme forms a relatively stable hydroperoxy flavin intermediate. Generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites. For example, N-oxygenation is largely responsible for the detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP). Formerly EC 1.13.12.11.	10	A0A024R934 A0A024R934 A0A480Y4M1 A0A480Y4M1 P16549 P16549 P50285 Q01740 Q01740 Q95LA2

CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

Functional Families

FunFam 144: Dimethylaniline monooxygenase [N-oxide-forming]

There are 1 EC terms in this cluster