The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"FAD/NAD(P)-binding domain
".
FunFam 104: Squalene monooxygenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
|
3 | P52019 (/ISS) P52019 (/ISS) P52020 (/ISS) |
|
Squalene monooxygenase activity GO:0004506
Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
|
2 | P52020 (/IDA) Q14534 (/IDA) |
|
Squalene monooxygenase activity GO:0004506
Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Squalene monooxygenase activity GO:0004506
Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
|
2 | P52019 (/ISS) P52019 (/ISS) |
|
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Squalene monooxygenase activity GO:0004506
Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
|
1 | Q14534 (/NAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q14534 (/IPI) |
|
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
|
1 | Q14534 (/IDA) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sterol biosynthetic process GO:0016126
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
3 | P52019 (/ISS) P52019 (/ISS) P52020 (/ISS) |
|
Cellular aromatic compound metabolic process GO:0006725
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Sterol biosynthetic process GO:0016126
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | Q14534 (/TAS) |
|
Cellular aromatic compound metabolic process GO:0006725
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
|
1 | P52020 (/IDA) |
|
Cholesterol metabolic process GO:0008203
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
|
1 | P52020 (/IMP) |
|
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
1 | P52020 (/IDA) |
|
Sterol biosynthetic process GO:0016126
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | Q14534 (/IDA) |
|
Sterol biosynthetic process GO:0016126
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | Q14534 (/NAS) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | Q14534 (/IMP) |
|
Regulation of cholesterol biosynthetic process GO:0045540
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
1 | Q14534 (/TAS) |
|
Lipid droplet formation GO:0140042
A process that results in the assembly, arrangement of constituent parts of a lipid droplet.
|
1 | Q14534 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P52019 (/ISS) P52019 (/ISS) P52020 (/ISS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | P52020 (/IDA) Q14534 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | P52019 (/ISO) P52019 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | P52019 (/ISS) P52019 (/ISS) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
1 | Q14534 (/TAS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q14534 (/IDA) |
