The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Rotenone-insensitive NADH-ubiquinone oxidoreductas...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
NADH dehydrogenase activity GO:0003954
Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
8 P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA)
NADH dehydrogenase activity GO:0003954
Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
7 Q07500 (/ISS) Q07500 (/ISS) Q07500 (/ISS) Q07500 (/ISS) Q07500 (/ISS) Q07500 (/ISS) Q07500 (/ISS)
NADH dehydrogenase (ubiquinone) activity GO:0008137
Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
3 P32340 (/IDA) P32340 (/IDA) P32340 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P32340 (/IPI) P32340 (/IPI) P32340 (/IPI)
NADH dehydrogenase (ubiquinone) activity GO:0008137
Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
2 O14121 (/ISO) O43090 (/ISO)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
NADH oxidation GO:0006116
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.
18 P32340 (/IDA) P32340 (/IDA) P32340 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA)
(8 more)
Glycolytic fermentation to ethanol GO:0019655
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.
15 P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) Q07500 (/IMP) Q07500 (/IMP)
(5 more)
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
11 P32340 (/IMP) P32340 (/IMP) P32340 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP)
(1 more)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
3 P32340 (/IDA) P32340 (/IDA) P32340 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
3 P32340 (/IMP) P32340 (/IMP) P32340 (/IMP)
NADH oxidation GO:0006116
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.
2 O14121 (/ISS) O43090 (/ISS)
Mitochondrial electron transport, NADH to ubiquinone GO:0006120
The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.
2 O14121 (/ISO) O43090 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
20 O14121 (/HDA) O43090 (/HDA) P32340 (/HDA) P32340 (/HDA) P32340 (/HDA) P40215 (/HDA) P40215 (/HDA) P40215 (/HDA) P40215 (/HDA) P40215 (/HDA)
(10 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
18 P32340 (/IDA) P32340 (/IDA) P32340 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA) P40215 (/IDA)
(8 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
15 P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) P40215 (/IMP) Q07500 (/IMP) Q07500 (/IMP)
(5 more)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 P32340 (/IDA) P32340 (/IDA) P32340 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 P32340 (/IMP) P32340 (/IMP) P32340 (/IMP)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 O14121 (/ISO) O43090 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q5AEC9 (/IDA) Q5AEC9 (/IDA)
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