The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphohistidine domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Phosphoenolpyruvate-protein phosphotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
15 P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA)
(5 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI)
(5 more)
Phosphoenolpyruvate-protein phosphotransferase activity GO:0008965
Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.
15 P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA)
(5 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
15 P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI) P08839 (/IPI)
(5 more)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
15 P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA)
(5 more)
Protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0008982
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
11 A0A0F7R8T7 (/ISS) A0A0F7R8T7 (/ISS) Q74BZ6 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS)
(1 more)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0009401
The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
15 P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA)
(5 more)
Phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0009401
The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
11 A0A0F7R8T7 (/ISS) A0A0F7R8T7 (/ISS) Q74BZ6 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS) Q9KTD7 (/ISS)
(1 more)
Phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0009401
The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
1 P45595 (/ISA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 P08839 (/HDA) P08839 (/HDA) P08839 (/HDA) P08839 (/HDA) P08839 (/HDA) P08839 (/HDA) P08839 (/HDA) P08839 (/HDA) P08839 (/HDA) P08839 (/HDA)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA)
(5 more)
Phosphoenolpyruvate-dependent sugar phosphotransferase complex GO:0019197
Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system).
15 P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA) P08839 (/IDA)
(5 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q74KD4 (/IDA) Q74KD4 (/IDA) Q74KD4 (/IDA) Q74KD4 (/IDA) Q74KD4 (/IDA)
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