The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histone deacetylase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Histone deacetylase 8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
4 Q8VH37 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
4 Q8VH37 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q9BY41 (/IPI) Q9BY41 (/IPI) Q9BY41 (/IPI)
Hsp70 protein binding GO:0030544
Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.
3 Q9BY41 (/IPI) Q9BY41 (/IPI) Q9BY41 (/IPI)
Hsp90 protein binding GO:0051879
Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
3 Q9BY41 (/IPI) Q9BY41 (/IPI) Q9BY41 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 B1WC68 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q8VH37 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 B1WC68 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q8VH37 (/ISO)
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
1 B1WC68 (/IDA)
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
1 Q8VH37 (/ISO)
Hsp70 protein binding GO:0030544
Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.
1 Q8VH37 (/ISO)
Hsp90 protein binding GO:0051879
Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
1 Q8VH37 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
4 Q8VH37 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
3 Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
3 Q9BY41 (/IMP) Q9BY41 (/IMP) Q9BY41 (/IMP)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
3 B1WC68 (/ISS) Q0VCB2 (/ISS) Q8VH37 (/ISS)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
3 Q9BY41 (/IDA) Q9BY41 (/IDA) Q9BY41 (/IDA)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
3 Q9BY41 (/IDA) Q9BY41 (/IDA) Q9BY41 (/IDA)
Regulation of telomere maintenance GO:0032204
Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
3 Q9BY41 (/IMP) Q9BY41 (/IMP) Q9BY41 (/IMP)
Regulation of cohesin loading GO:0071922
Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
3 Q9BY41 (/IMP) Q9BY41 (/IMP) Q9BY41 (/IMP)
Regulation of cohesin loading GO:0071922
Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
3 B1WC68 (/ISS) Q0VCB2 (/ISS) Q8VH37 (/ISS)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
1 Q8VH37 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 B1WC68 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q8VH37 (/ISO)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q8VH37 (/ISO)
Regulation of telomere maintenance GO:0032204
Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
1 Q8VH37 (/ISO)
Cellular response to trichostatin A GO:0035984
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.
1 B1WC68 (/IDA)
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
1 B1WC68 (/IMP)
Regulation of cohesin loading GO:0071922
Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
1 Q8VH37 (/ISO)
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
1 B1WC68 (/IDA)
Negative regulation of histone H3-K9 acetylation GO:2000616
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation.
1 B1WC68 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A6NGJ7 (/IDA) B1WC68 (/IDA) E7EVA8 (/IDA) Q9BY41 (/IDA) Q9BY41 (/IDA) Q9BY41 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A6NGJ7 (/IDA) E7EVA8 (/IDA) Q9BY41 (/IDA) Q9BY41 (/IDA) Q9BY41 (/IDA)
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
4 Q8VH37 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q8VH37 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q8VH37 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
3 Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q9BY41 (/TAS) Q9BY41 (/TAS) Q9BY41 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8VH37 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8VH37 (/ISO)
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