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CATH Superfamily 3.40.800.20

Histone deacetylase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histone deacetylase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: histone deacetylase 6

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histone deacetylase. [EC: 3.5.1.98]
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
  • A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone.
  • The reaction of this enzyme is opposite to that of EC 2.3.1.48.
  • Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization.
  • Histone acetylation plays an important role in regulation of gene expression.
  • In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation.
  • May be identical to EC 3.5.1.17.
 28 A0A024QZ26 A0A024QZ26 A0A024QZ26 A0A024QZ26 A6ZS47 A6ZS47 A6ZS47 A6ZS47 G2WM72 G2WM72
(18 more...)
Acetylspermidine deacetylase. [EC: 3.5.1.48]
N(8)-acetylspermidine + H(2)O = acetate + spermidine.
  • It was initially thought that N(1)-acetylspermidine was the substrate for this deacetylase reaction but this has since been disproved.
 4 F1QCV2 Q569C4 Q6P3E7 Q969S8
Acetylputrescine deacetylase. [EC: 3.5.1.62]
N-acetylputrescine + H(2)O = acetate + putrescine.
  • The enzyme from Micrococcus luteus also acts on N(8)-acetylspermidine and acetylcadaverine, but more slowly.
 4 F1QCV2 Q569C4 Q6P3E7 Q969S8
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