The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Histone deacetylase domain
".
FunFam 3: Histone deacetylase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 68 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
17 |
B1WBY8 (/IPI)
F7ENH8 (/IPI)
O09106 (/IPI)
O09106 (/IPI)
O09106 (/IPI)
P70288 (/IPI)
Q13547 (/IPI)
Q13547 (/IPI)
Q13547 (/IPI)
Q4QQW4 (/IPI)
(7 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
12 |
B1WBY8 (/IPI)
F7ENH8 (/IPI)
O09106 (/IPI)
O09106 (/IPI)
O09106 (/IPI)
Q13547 (/IPI)
Q13547 (/IPI)
Q13547 (/IPI)
Q4QQW4 (/IPI)
Q92769 (/IPI)
(2 more) |
|
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
|
12 |
Q13547 (/ISS)
Q13547 (/ISS)
Q13547 (/ISS)
Q32PJ8 (/ISS)
Q32PJ8 (/ISS)
Q4QQW4 (/ISS)
Q5RAG0 (/ISS)
Q5RAG0 (/ISS)
Q5RAG0 (/ISS)
Q92769 (/ISS)
(2 more) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
11 |
O09106 (/IDA)
O09106 (/IDA)
O09106 (/IDA)
P70288 (/IDA)
Q13547 (/IDA)
Q13547 (/IDA)
Q13547 (/IDA)
Q92769 (/IDA)
Q92769 (/IDA)
Q92769 (/IDA)
(1 more) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
11 |
O09106 (/TAS)
O09106 (/TAS)
O09106 (/TAS)
P56517 (/TAS)
P56518 (/TAS)
P56519 (/TAS)
P70288 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
(1 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
11 |
O09106 (/TAS)
O09106 (/TAS)
O09106 (/TAS)
P56517 (/TAS)
P56518 (/TAS)
P56519 (/TAS)
P70288 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
(1 more) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
9 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q32PJ8 (/ISS) Q32PJ8 (/ISS) Q4QQW4 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) |
|
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
|
9 | O09106 (/IPI) O09106 (/IPI) O09106 (/IPI) Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) Q92769 (/IPI) Q92769 (/IPI) Q92769 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
9 | B1WBY8 (/IPI) F7ENH8 (/IPI) P70288 (/IPI) Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) Q92769 (/IPI) Q92769 (/IPI) Q92769 (/IPI) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
9 | Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) Q6IT96 (/IPI) Q6IT96 (/IPI) Q6IT96 (/IPI) Q92769 (/IPI) Q92769 (/IPI) Q92769 (/IPI) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
7 | Q32PJ8 (/ISS) Q32PJ8 (/ISS) Q4QQW4 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) Q94517 (/ISS) |
|
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
|
7 | B1WBY8 (/IDA) F7ENH8 (/IDA) O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) Q4QQW4 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
6 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
6 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
6 | Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) Q92769 (/IPI) Q92769 (/IPI) Q92769 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
5 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) Q4QQW4 (/IDA) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
5 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q4QQW4 (/IMP) Q94517 (/IMP) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
5 | B1WBY8 (/IDA) F7ENH8 (/IDA) O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
4 | P70288 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Krueppel-associated box domain binding GO:0035851
Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.
|
4 | O09106 (/IPI) O09106 (/IPI) O09106 (/IPI) P70288 (/IPI) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | Q13547 (/IGI) Q13547 (/IGI) Q13547 (/IGI) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
|
3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
|
3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
3 | Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
3 | Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
3 | Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
3 | Q92769 (/HDA) Q92769 (/HDA) Q92769 (/HDA) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
3 | Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
3 | Q92769 (/IDA) Q92769 (/IDA) Q92769 (/IDA) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
3 | Q13547 (/IPI) Q13547 (/IPI) Q13547 (/IPI) |
|
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
2 | B1WBY8 (/IDA) F7ENH8 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P70288 (/IDA) |
|
RNA polymerase II transcription corepressor binding GO:0001226
Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II.
|
1 | P70288 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q94517 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q94517 (/NAS) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
1 | Q94517 (/NAS) |
|
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
1 | P70288 (/ISO) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
1 | P70288 (/IDA) |
|
Histone deacetylase activity (H4-K16 specific) GO:0034739
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
|
1 | P70288 (/IMP) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P70288 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q4QQW4 (/IDA) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
1 | P70288 (/ISO) |
There are 200 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
12 |
Q13547 (/ISS)
Q13547 (/ISS)
Q13547 (/ISS)
Q32PJ8 (/ISS)
Q32PJ8 (/ISS)
Q4QQW4 (/ISS)
Q5RAG0 (/ISS)
Q5RAG0 (/ISS)
Q5RAG0 (/ISS)
Q92769 (/ISS)
(2 more) |
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
11 |
O09106 (/TAS)
O09106 (/TAS)
O09106 (/TAS)
P56517 (/TAS)
P56518 (/TAS)
P56519 (/TAS)
P70288 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
(1 more) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
9 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q4QQW4 (/IMP) Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
9 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q32PJ8 (/ISS) Q32PJ8 (/ISS) Q4QQW4 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) |
|
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
|
9 | Q32PJ8 (/ISS) Q32PJ8 (/ISS) Q4QQW4 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) Q5RAG0 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
8 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q94517 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) Q13547 (/IGI) Q13547 (/IGI) Q13547 (/IGI) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
7 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) Q94517 (/IMP) |
|
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
|
7 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
|
7 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
7 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) Q13547 (/IGI) Q13547 (/IGI) Q13547 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
6 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
6 | Q13547 (/IC) Q13547 (/IC) Q13547 (/IC) Q92769 (/IC) Q92769 (/IC) Q92769 (/IC) |
|
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
6 | Q13547 (/TAS) Q13547 (/TAS) Q13547 (/TAS) Q92769 (/TAS) Q92769 (/TAS) Q92769 (/TAS) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Epidermal cell differentiation GO:0009913
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
|
6 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
6 | A0A0R4IDY9 (/IGI) A0A2R8QIW0 (/IGI) F1R653 (/IGI) Q5RKQ4 (/IGI) Q6P2A8 (/IGI) Q8JIY7 (/IGI) |
|
Positive regulation of receptor biosynthetic process GO:0010870
Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
6 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
6 | A0A0R4IDY9 (/IGI) A0A2R8QIW0 (/IGI) F1R653 (/IGI) Q5RKQ4 (/IGI) Q6P2A8 (/IGI) Q8JIY7 (/IGI) |
|
Facial nucleus development GO:0021754
The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Rostrocaudal neural tube patterning GO:0021903
The process in which the neural tube is divided into specific regions along the rostrocaudal axis.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Melanocyte differentiation GO:0030318
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Exocrine pancreas development GO:0031017
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Osteoblast proliferation GO:0033687
The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Odontogenesis of dentin-containing tooth GO:0042475
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
|
6 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
|
6 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
ATP-dependent chromatin remodeling GO:0043044
Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors.
|
6 | Q13547 (/HDA) Q13547 (/HDA) Q13547 (/HDA) Q92769 (/HDA) Q92769 (/HDA) Q92769 (/HDA) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
6 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Determination of dorsal identity GO:0048263
Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Embryonic skeletal system development GO:0048706
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Oligodendrocyte differentiation GO:0048709
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Peripheral nervous system neuron development GO:0048935
The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Epithelial cell proliferation GO:0050673
The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
|
6 | A0A0R4IDY9 (/IGI) A0A2R8QIW0 (/IGI) F1R653 (/IGI) Q5RKQ4 (/IGI) Q6P2A8 (/IGI) Q8JIY7 (/IGI) |
|
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Hematopoietic stem cell differentiation GO:0060218
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
6 | A0A0R4IDY9 (/IMP) A0A2R8QIW0 (/IMP) F1R653 (/IMP) Q5RKQ4 (/IMP) Q6P2A8 (/IMP) Q8JIY7 (/IMP) |
|
Hair follicle placode formation GO:0060789
The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.
|
6 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Eyelid development in camera-type eye GO:0061029
The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.
|
6 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Fungiform papilla formation GO:0061198
The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue.
|
6 | Q13547 (/ISS) Q13547 (/ISS) Q13547 (/ISS) Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
|
6 | Q13547 (/TAS) Q13547 (/TAS) Q13547 (/TAS) Q92769 (/TAS) Q92769 (/TAS) Q92769 (/TAS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
5 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) Q4QQW4 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
4 | P70288 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Epidermal cell differentiation GO:0009913
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
4 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) Q94517 (/IMP) |
|
Positive regulation of receptor biosynthetic process GO:0010870
Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Positive regulation of interleukin-1 production GO:0032732
Any process that activates or increases the frequency, rate, or extent of interleukin-1 production.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
4 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) |
|
Odontogenesis of dentin-containing tooth GO:0042475
The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Hair follicle placode formation GO:0060789
The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Eyelid development in camera-type eye GO:0061029
The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Fungiform papilla formation GO:0061198
The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Negative regulation of peptidyl-lysine acetylation GO:2000757
Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
|
4 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) P70288 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q13547 (/TAS) Q13547 (/TAS) Q13547 (/TAS) |
|
Response to amphetamine GO:0001975
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Maintenance of chromatin silencing GO:0006344
The maintenance of chromatin in a transcriptionally silent state such as heterochromatin.
|
3 | Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Methylation-dependent chromatin silencing GO:0006346
Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
3 | Q13547 (/IGI) Q13547 (/IGI) Q13547 (/IGI) |
|
Methylation-dependent chromatin silencing GO:0006346
Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q13547 (/IGI) Q13547 (/IGI) Q13547 (/IGI) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
|
3 | O09106 (/IMP) O09106 (/IMP) O09106 (/IMP) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
3 | Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
|
3 | Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
|
3 | B1WBY8 (/IEP) F7ENH8 (/IEP) Q4QQW4 (/IEP) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
3 | B1WBY8 (/IEP) F7ENH8 (/IEP) Q4QQW4 (/IEP) |
|
Positive regulation of interleukin-1 production GO:0032732
Any process that activates or increases the frequency, rate, or extent of interleukin-1 production.
|
3 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q4QQW4 (/IMP) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
3 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q4QQW4 (/IMP) |
|
Positive regulation of collagen biosynthetic process GO:0032967
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
|
3 | Q92769 (/IC) Q92769 (/IC) Q92769 (/IC) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
3 | B1WBY8 (/IEP) F7ENH8 (/IEP) Q4QQW4 (/IEP) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
3 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q4QQW4 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | Q13547 (/TAS) Q13547 (/TAS) Q13547 (/TAS) |
|
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
|
3 | O09106 (/IGI) O09106 (/IGI) O09106 (/IGI) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
3 | Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Negative regulation by host of viral transcription GO:0043922
Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
|
3 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) |
|
Negative regulation by host of viral transcription GO:0043922
Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Negative regulation of MHC class II biosynthetic process GO:0045347
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.
|
3 | Q92769 (/IC) Q92769 (/IC) Q92769 (/IC) |
|
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
|
3 | Q13547 (/TAS) Q13547 (/TAS) Q13547 (/TAS) |
|
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
3 | Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q92769 (/IC) Q92769 (/IC) Q92769 (/IC) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q92769 (/IC) Q92769 (/IC) Q92769 (/IC) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q92769 (/IMP) Q92769 (/IMP) Q92769 (/IMP) |
|
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
|
3 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q4QQW4 (/IMP) |
|
Regulation of endopeptidase activity GO:0052548
Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
3 | Q13547 (/IMP) Q13547 (/IMP) Q13547 (/IMP) |
|
Regulation of endopeptidase activity GO:0052548
Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
|
3 | B1WBY8 (/IEP) F7ENH8 (/IEP) Q4QQW4 (/IEP) |
|
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
|
3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
|
Negative regulation of androgen receptor signaling pathway GO:0060766
Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
|
3 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q4QQW4 (/IMP) |
|
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
|
3 | Q92769 (/ISS) Q92769 (/ISS) Q92769 (/ISS) |
|
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Regulation of amyloid-beta clearance GO:1900221
Any process that modulates the frequency, rate or extent of amyloid-beta clearance.
|
3 | Q13547 (/IC) Q13547 (/IC) Q13547 (/IC) |
|
Beta-catenin-TCF complex assembly GO:1904837
The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex.
|
3 | Q13547 (/TAS) Q13547 (/TAS) Q13547 (/TAS) |
|
Positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343
Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Positive regulation of type B pancreatic cell apoptotic process GO:2000676
Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
Negative regulation of peptidyl-lysine acetylation GO:2000757
Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation.
|
3 | B1WBY8 (/IMP) F7ENH8 (/IMP) Q4QQW4 (/IMP) |
|
Response to amphetamine GO:0001975
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Cardiac muscle hypertrophy GO:0003300
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
2 | B1WBY8 (/IMP) F7ENH8 (/IMP) |
|
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | B1WBY8 (/IMP) F7ENH8 (/IMP) |
|
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
2 | B1WBY8 (/IMP) F7ENH8 (/IMP) |
|
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Negative regulation of dendritic spine development GO:0061000
Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
|
2 | B1WBY8 (/IMP) F7ENH8 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
2 | B1WBY8 (/IDA) F7ENH8 (/IDA) |
|
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Positive regulation of male mating behavior GO:1902437
Any process that activates or increases the frequency, rate or extent of male mating behavior.
|
2 | B1WBY8 (/IMP) F7ENH8 (/IMP) |
|
Cellular response to dopamine GO:1903351
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.
|
2 | B1WBY8 (/IEP) F7ENH8 (/IEP) |
|
Response to amphetamine GO:0001975
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
|
1 | Q4QQW4 (/IMP) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | Q94517 (/IGI) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | Q94517 (/IMP) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | Q94517 (/IPI) |
|
Maintenance of chromatin silencing GO:0006344
The maintenance of chromatin in a transcriptionally silent state such as heterochromatin.
|
1 | P70288 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q94517 (/IDA) |
|
Blastoderm segmentation GO:0007350
The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.
|
1 | Q94517 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q4QQW4 (/IDA) |
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | Q94517 (/IMP) |
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | Q94517 (/TAS) |
|
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
|
1 | P70288 (/ISO) |
|
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P70288 (/IDA) |
|
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P70288 (/ISO) |
|
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
|
1 | P70288 (/IMP) |
|
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
|
1 | Q94517 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
1 | P70288 (/IGI) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
1 | Q94517 (/NAS) |
|
Chromosome condensation GO:0030261
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
|
1 | Q94517 (/IMP) |
|
Negative regulation of histone methylation GO:0031061
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones.
|
1 | Q94517 (/IMP) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q4QQW4 (/IDA) |
|
Regulation of histone acetylation GO:0035065
Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
1 | Q94517 (/IMP) |
|
Cellular response to trichostatin A GO:0035984
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.
|
1 | P70288 (/IDA) |
|
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
1 | P70288 (/ISO) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P70288 (/ISO) |
|
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | Q4QQW4 (/IMP) |
|
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
|
1 | Q94517 (/IMP) |
|
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
1 | P70288 (/ISO) |
|
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
|
1 | Q94517 (/IMP) |
|
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
|
1 | Q94517 (/IPI) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q94517 (/IEP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q94517 (/IGI) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q94517 (/NAS) |
|
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
1 | Q4QQW4 (/IMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
1 | Q94517 (/TAS) |
|
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
|
1 | Q94517 (/IMP) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P70288 (/IDA) |
|
Regulation of protein kinase B signaling GO:0051896
Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | P70288 (/IMP) |
|
Cardiac muscle cell development GO:0055013
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
|
1 | P70288 (/IMP) |
|
Negative regulation of cardiac muscle cell proliferation GO:0060044
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.
|
1 | P70288 (/IMP) |
|
Regulation of sarcomere organization GO:0060297
Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
1 | P70288 (/IMP) |
|
Negative regulation of dendritic spine development GO:0061000
Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
|
1 | P70288 (/ISO) |
|
Negative regulation of histone H3-K27 methylation GO:0061086
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
|
1 | Q94517 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | P70288 (/ISO) |
|
Histone H3-K27 methylation GO:0070734
The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone.
|
1 | P70288 (/IMP) |
|
Dendrite guidance GO:0070983
The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q94517 (/IMP) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | Q4QQW4 (/IEP) |
|
Regulation of protein deacetylation GO:0090311
Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
1 | P70288 (/IGI) |
|
Positive regulation of male mating behavior GO:1902437
Any process that activates or increases the frequency, rate or extent of male mating behavior.
|
1 | P70288 (/ISO) |
|
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
|
1 | Q94517 (/IGI) |
|
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
|
1 | Q94517 (/IMP) |
|
Negative regulation of pri-miRNA transcription by RNA polymerase II GO:1902894
Any process that stops, prevents or reduces the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II.
|
1 | P70288 (/IGI) |
|
Negative regulation of pri-miRNA transcription by RNA polymerase II GO:1902894
Any process that stops, prevents or reduces the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II.
|
1 | P70288 (/IMP) |
|
Positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343
Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production.
|
1 | Q4QQW4 (/IMP) |
|
Positive regulation of type B pancreatic cell apoptotic process GO:2000676
Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.
|
1 | Q4QQW4 (/IMP) |
|
Negative regulation of response to gamma radiation GO:2001229
Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation.
|
1 | Q94517 (/IMP) |
There are 47 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
14 |
B1WBY8 (/IDA)
F7ENH8 (/IDA)
O09106 (/IDA)
O09106 (/IDA)
O09106 (/IDA)
P70288 (/IDA)
Q13547 (/IDA)
Q13547 (/IDA)
Q13547 (/IDA)
Q4QQW4 (/IDA)
(4 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
14 |
O09106 (/TAS)
O09106 (/TAS)
O09106 (/TAS)
P56517 (/TAS)
P56518 (/TAS)
P56519 (/TAS)
P70288 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
(4 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
12 |
O09106 (/TAS)
O09106 (/TAS)
O09106 (/TAS)
P70288 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
Q4QQW4 (/TAS)
Q92769 (/TAS)
Q92769 (/TAS)
(2 more) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
11 |
O09106 (/TAS)
O09106 (/TAS)
O09106 (/TAS)
P56517 (/TAS)
P56518 (/TAS)
P56519 (/TAS)
P70288 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
Q13547 (/TAS)
(1 more) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
10 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q4QQW4 (/IDA) Q92769 (/IDA) Q92769 (/IDA) Q92769 (/IDA) |
|
NuRD complex GO:0016581
An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
|
9 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q92769 (/IDA) Q92769 (/IDA) Q92769 (/IDA) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
7 | B1WBY8 (/IDA) F7ENH8 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q4QQW4 (/IDA) Q94517 (/IDA) |
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Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
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7 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
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Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
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6 | Q13547 (/HDA) Q13547 (/HDA) Q13547 (/HDA) Q92769 (/HDA) Q92769 (/HDA) Q92769 (/HDA) |
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Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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6 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q6IT96 (/IDA) Q6IT96 (/IDA) Q6IT96 (/IDA) |
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Sin3 complex GO:0016580
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
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6 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) Q92769 (/IDA) Q92769 (/IDA) Q92769 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
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6 | Q13547 (/HDA) Q13547 (/HDA) Q13547 (/HDA) Q92769 (/HDA) Q92769 (/HDA) Q92769 (/HDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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5 | B1WBY8 (/IDA) F7ENH8 (/IDA) Q92769 (/IDA) Q92769 (/IDA) Q92769 (/IDA) |
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Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
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5 | O09106 (/IPI) O09106 (/IPI) O09106 (/IPI) P70288 (/IPI) Q94517 (/IPI) |
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Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
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Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
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4 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) P70288 (/IDA) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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4 | P56517 (/TAS) P56518 (/TAS) P56519 (/TAS) Q94517 (/TAS) |
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Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
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4 | O09106 (/IPI) O09106 (/IPI) O09106 (/IPI) P70288 (/IPI) |
|
Sin3 complex GO:0016580
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
NuRD complex GO:0016581
An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
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4 | O09106 (/IPI) O09106 (/IPI) O09106 (/IPI) Q94517 (/IPI) |
|
NuRD complex GO:0016581
An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
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4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
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Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
4 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) P70288 (/ISO) |
|
ESC/E(Z) complex GO:0035098
A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
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4 | Q92769 (/IDA) Q92769 (/IDA) Q92769 (/IDA) Q94517 (/IDA) |
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Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
3 | O09106 (/IPI) O09106 (/IPI) O09106 (/IPI) |
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Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
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Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
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Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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3 | Q13547 (/IDA) Q13547 (/IDA) Q13547 (/IDA) |
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Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
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Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
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Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
3 | O09106 (/IDA) O09106 (/IDA) O09106 (/IDA) |
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Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
3 | O09106 (/ISO) O09106 (/ISO) O09106 (/ISO) |
|
ESC/E(Z) complex GO:0035098
A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
|
2 | P56519 (/ISS) P70288 (/ISS) |
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Replication fork GO:0005657
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
|
1 | P70288 (/IDA) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
1 | Q94517 (/IDA) |
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Polytene chromosome interband GO:0005705
A stretch of less tightly packed chromatin along the polytene chromosome, found between bands.
|
1 | Q94517 (/IDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P70288 (/ISO) |
|
Sin3 complex GO:0016580
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
1 | Q94517 (/NAS) |
|
NuRD complex GO:0016581
An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
|
1 | Q94517 (/NAS) |
|
Myb complex GO:0031523
A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.
|
1 | Q94517 (/IDA) |
|
ESC/E(Z) complex GO:0035098
A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
|
1 | P70288 (/ISO) |
|
ESC/E(Z) complex GO:0035098
A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
|
1 | Q94517 (/TAS) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q4QQW4 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q4QQW4 (/IDA) |
|
Sin3-type complex GO:0070822
Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.
|
1 | Q94517 (/IDA) |
|
RNA polymerase II transcription repressor complex GO:0090571
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter.
|
1 | P70288 (/IDA) |
