The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ureohydrolase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Arginase-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Arginase activity GO:0004053
Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
2 P07824 (/IDA) Q61176 (/IDA)
Arginase activity GO:0004053
Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
1 Q61176 (/ISO)
Arginase activity GO:0004053
Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
1 P05089 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P05089 (/IPI)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 P07824 (/IDA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 Q61176 (/ISO)

There are 54 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Urea cycle GO:0000050
The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
1 P07824 (/IDA)
Urea cycle GO:0000050
The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
1 Q61176 (/ISO)
Urea cycle GO:0000050
The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
1 P05089 (/TAS)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 P07824 (/IEP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 P07824 (/IDA)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 Q61176 (/ISO)
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 P07824 (/IDA)
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 Q61176 (/ISO)
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 P05089 (/TAS)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 P07824 (/IEP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P07824 (/IEP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 P07824 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 P07824 (/IEP)
Response to manganese ion GO:0010042
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus.
1 P07824 (/IEP)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 P07824 (/IEP)
Response to selenium ion GO:0010269
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion.
1 P07824 (/IEP)
Regulation of L-arginine import GO:0010963
Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle.
1 P07824 (/IDA)
Regulation of L-arginine import GO:0010963
Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle.
1 Q61176 (/ISO)
Response to amine GO:0014075
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
1 P07824 (/IEP)
Arginine catabolic process to ornithine GO:0019547
The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.
1 P07824 (/IDA)
Arginine catabolic process to ornithine GO:0019547
The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.
1 Q61176 (/ISO)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
1 P07824 (/IEP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P07824 (/IEP)
Collagen biosynthetic process GO:0032964
The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 P07824 (/IMP)
Collagen biosynthetic process GO:0032964
The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 Q61176 (/ISO)
Response to vitamin A GO:0033189
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
1 P07824 (/IEP)
Response to vitamin E GO:0033197
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.
1 P07824 (/IEP)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
1 P05089 (/IDA)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
1 Q61176 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P07824 (/IEP)
Defense response to protozoan GO:0042832
Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.
1 Q61176 (/IMP)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 P07824 (/IEP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P05089 (/TAS)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P07824 (/IEP)
Negative regulation of activated T cell proliferation GO:0046007
Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
1 Q61176 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 P07824 (/IEP)
Response to steroid hormone GO:0048545
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
1 P07824 (/IEP)
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
1 P07824 (/IEP)
Response to methylmercury GO:0051597
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.
1 P07824 (/IEP)
Mammary gland involution GO:0060056
The tissue remodeling that removes differentiated mammary epithelia during weaning.
1 P07824 (/IEP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 P07824 (/IEP)
Negative regulation of interferon-gamma-mediated signaling pathway GO:0060336
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
1 P05089 (/IMP)
Negative regulation of interferon-gamma-mediated signaling pathway GO:0060336
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
1 Q61176 (/ISO)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
1 P07824 (/IDA)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
1 Q61176 (/ISO)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P07824 (/IEP)
Positive regulation of neutrophil mediated killing of fungus GO:0070965
Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil.
1 P05089 (/IMP)
Positive regulation of neutrophil mediated killing of fungus GO:0070965
Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil.
1 Q61176 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P07824 (/IEP)
Cellular response to interleukin-4 GO:0071353
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
1 P07824 (/IEP)
Cellular response to glucagon stimulus GO:0071377
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
1 P07824 (/IEP)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 P07824 (/IEP)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 P07824 (/IEP)
Negative regulation of T-helper 2 cell cytokine production GO:2000552
Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production.
1 Q61176 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P05089 (/IDA) P07824 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P05089 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q61176 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P05089 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P07824 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61176 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P05089 (/TAS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 P07824 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q61176 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P05089 (/TAS)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 P05089 (/TAS)
Specific granule lumen GO:0035580
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 P05089 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P07824 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q61176 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P07824 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q61176 (/ISO)
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