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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 71: Kynurenine/alpha-aminoadipate aminotransferase, mi...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Kynurenine--oxoglutarate transaminase. [EC: 2.6.1.7]
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
  • Also acts on 3-hydroxykynurenine.
  • The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
 7 Q4W5N8 Q4W5N8 Q5E9N4 Q64602 Q8N5Z0 Q8N5Z0 Q9WVM8
2-aminoadipate transaminase. [EC: 2.6.1.39]
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
    		 7 Q4W5N8 Q4W5N8 Q5E9N4 Q64602 Q8N5Z0 Q8N5Z0 Q9WVM8
    Aromatic-amino-acid transaminase. [EC: 2.6.1.57]
    An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
    • L-methionine can also act as donor, more slowly.
    • Oxaloacetate can act as acceptor.
    • Controlled proteolysis converts the enzyme to EC 2.6.1.1.
    		 1 Q54K00