The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 66: Aspartate aminotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
9 O42652 (/ISS) O94320 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q22067 (/ISS) Q54SF7 (/ISS) Q8EEH6 (/ISS)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
5 Q9KM75 (/ISS) Q9KM75 (/ISS) Q9KM75 (/ISS) Q9KM75 (/ISS) Q9KM75 (/ISS)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
4 Q01802 (/ISA) Q01802 (/ISA) Q01802 (/ISA) Q01802 (/ISA)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
2 Q5ASM1 (/RCA) Q5ASM1 (/RCA)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
1 Q22067 (/IDA)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
1 O42652 (/ISO)
Aromatic-amino-acid:2-oxoglutarate aminotransferase activity GO:0008793
Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
1 Q5LM44 (/ISS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
8 O42652 (/ISS) O94320 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q22067 (/ISS) Q54SF7 (/ISS)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
8 O42652 (/ISS) O94320 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q22067 (/ISS) Q54SF7 (/ISS)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
8 O42652 (/ISS) O94320 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q22067 (/ISS) Q54SF7 (/ISS)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
5 Q9KM75 (/ISS) Q9KM75 (/ISS) Q9KM75 (/ISS) Q9KM75 (/ISS) Q9KM75 (/ISS)
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
4 Q01802 (/IMP) Q01802 (/IMP) Q01802 (/IMP) Q01802 (/IMP)
Replicative cell aging GO:0001302
The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
4 Q01802 (/IMP) Q01802 (/IMP) Q01802 (/IMP) Q01802 (/IMP)
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
3 O94320 (/ISS) Q54SF7 (/ISS) Q8EEH6 (/ISS)
Tyrosine catabolic process GO:0006572
The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
3 P43336 (/IMP) P43336 (/IMP) P43336 (/IMP)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
2 Q5ASM1 (/RCA) Q5ASM1 (/RCA)
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 O42652 (/ISO)
Aspartate catabolic process GO:0006533
The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 O94320 (/ISS)
Cysteine metabolic process GO:0006534
The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.
1 O94320 (/NAS)
Aromatic amino acid family biosynthetic process GO:0009073
The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
1 Q5LM44 (/ISS)
Asparagine biosynthetic process from oxaloacetate GO:0019266
The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate.
1 O94320 (/ISS)
Positive regulation of glutamate metabolic process GO:2000213
Any process that activates or increases the frequency, rate or extent of glutamate metabolic process.
1 Q22067 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 O94320 (/HDA) Q01802 (/HDA) Q01802 (/HDA) Q01802 (/HDA) Q01802 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 O94320 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS) Q01802 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q01802 (/IDA) Q01802 (/IDA) Q01802 (/IDA) Q01802 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O42652 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q22067 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 O94320 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O42652 (/HDA)