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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Acetylornithine aminotransferase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Succinylornithine transaminase. [EC: 2.6.1.81]
N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate.
  • Also acts on N(2)-acetyl-L-ornithine and L-ornithine, but more slowly.
  • In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, EC 2.6.1.11 and EC 2.6.1.13 activities are catalyzed by the same enzyme, but this is not the case in all species.
  • This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine.
  • This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA.
  • The five enzymes involved in this pathway are EC 2.3.1.109, EC 3.5.3.23, EC 2.6.1.81, EC 1.2.1.71 and EC 3.5.1.96.
 4381 A0A029HYL6 A0A029HYL6 A0A029HYL6 A0A029HYL6 A0A029HYL6 A0A029HYL6 A0A029HYL6 A0A029HYL6 A0A029HYL6 A0A029HYL6
(4371 more...)
Putrescine--2-oxoglutarate transaminase. [EC: 2.6.1.82]
Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H(2)O.
  • The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline, which is a substrate for EC 1.2.1.19.
  • Cadaverine and spermidine can also act as substrates.
  • Forms part of the arginine catabolism pathway.
  • Cf. EC 2.6.1.113.
 3445 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0 A0A023Z3B0
(3435 more...)
Acetylornithine transaminase. [EC: 2.6.1.11]
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
  • Also acts on L-ornithine and N(2)-succinyl-L-ornithine.
 2953 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7
(2943 more...)
Succinyldiaminopimelate transaminase. [EC: 2.6.1.17]
N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2- L-amino-6-oxoheptanedioate + L-glutamate.
    		 2636 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7 A0A028APE7
    (2626 more...)
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