View in Gene3D

CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 33: Aspartate aminotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
 37 A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS)
(27 more)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
 25 E9L7A5 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA)
(15 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 17 P77806 (/IPI) P77806 (/IPI) P77806 (/IPI) P77806 (/IPI) P77806 (/IPI) P77806 (/IPI) P77806 (/IPI) P77806 (/IPI) P77806 (/IPI) P77806 (/IPI)
(7 more)
Methionine-oxo-acid transaminase activity GO:0010326
Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid.
 17 P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA) P77806 (/IDA)
(7 more)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
 7 Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
 2 E9L7A5 (/IDA) Q9SIE1 (/IDA)
Aspartate-prephenate aminotransferase activity GO:0033853
Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate.
 2 E9L7A5 (/IDA) Q9SIE1 (/IDA)
Glutamate-prephenate aminotransferase activity GO:0033854
Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate.
 2 E9L7A5 (/IDA) Q9SIE1 (/IDA)
L-cysteine:2-oxoglutarate aminotransferase activity GO:0047801
Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
 2 Q389E5 (/IDA) Q389E5 (/IDA)
L-leucine transaminase activity GO:0052654
Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid.
 2 Q389E5 (/IDA) Q389E5 (/IDA)
L-glutamine aminotransferase activity GO:0070548
Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid.
 2 Q389E5 (/IDA) Q389E5 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 1 E9L7A5 (/IDA)
Asparagine-oxo-acid transaminase activity GO:0047297
Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate.
 1 Q8DTM1 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
 34 A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS) A0A0J1KGX2 (/ISS)
(24 more)
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
 7 Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA) Q9HUI9 (/IDA)
Arginine catabolic process to succinate GO:0019545
The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate.
 7 Q9HUI9 (/IMP) Q9HUI9 (/IMP) Q9HUI9 (/IMP) Q9HUI9 (/IMP) Q9HUI9 (/IMP) Q9HUI9 (/IMP) Q9HUI9 (/IMP)
Aspartate catabolic process GO:0006533
The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
 3 Q2GK59 (/ISS) Q2GK59 (/ISS) Q2GK59 (/ISS)
Aromatic amino acid family biosynthetic process, prephenate pathway GO:0009095
The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate.
 2 E9L7A5 (/IDA) Q9SIE1 (/IDA)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
 1 Q9SIE1 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 2 Q389E5 (/IDA) Q389E5 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
 1 Q9SIE1 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
 1 Q9SIE1 (/IDA)