The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Aspartate aminotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
16 P00505 (/ISS) P00506 (/ISS) P00506 (/ISS) P00507 (/ISS) P05202 (/ISS) P08907 (/ISS) P12344 (/ISS) P12345 (/ISS) Q28F67 (/ISS) Q4R559 (/ISS)
(6 more)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
4 P00505 (/IDA) P00507 (/IDA) P00508 (/IDA) P05202 (/IDA)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
2 Q5BBT7 (/RCA) Q5BBT7 (/RCA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P00505 (/HDA)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
1 P00507 (/IMP)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
1 P05202 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P00507 (/IDA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P05202 (/ISO)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
1 P00507 (/IDA)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
1 P05202 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P00507 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P05202 (/ISO)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P00507 (/IDA)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P00507 (/IMP)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 P05202 (/ISO)
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
1 P00507 (/IDA)
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
1 P05202 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P00507 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P00508 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P05202 (/ISO)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
16 P00505 (/ISS) P00506 (/ISS) P00506 (/ISS) P00507 (/ISS) P05202 (/ISS) P08907 (/ISS) P12344 (/ISS) P12345 (/ISS) Q28F67 (/ISS) Q4R559 (/ISS)
(6 more)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
16 P00505 (/ISS) P00506 (/ISS) P00506 (/ISS) P00507 (/ISS) P05202 (/ISS) P08907 (/ISS) P12344 (/ISS) P12345 (/ISS) Q28F67 (/ISS) Q4R559 (/ISS)
(6 more)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
16 P00505 (/ISS) P00506 (/ISS) P00506 (/ISS) P00507 (/ISS) P05202 (/ISS) P08907 (/ISS) P12344 (/ISS) P12345 (/ISS) Q28F67 (/ISS) Q4R559 (/ISS)
(6 more)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
2 P00505 (/TAS) P00508 (/TAS)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
2 P00507 (/IDA) P05202 (/IDA)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
2 P00507 (/TAS) P00508 (/TAS)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
2 Q5BBT7 (/RCA) Q5BBT7 (/RCA)
Aromatic amino acid family biosynthetic process GO:0009073
The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
2 Q5BBT7 (/RCA) Q5BBT7 (/RCA)
Glutamate catabolic process to 2-oxoglutarate GO:0019551
The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.
2 P00507 (/IDA) P05202 (/IDA)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 P00508 (/IDA)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
1 P05202 (/ISO)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 P12345 (/TAS)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
1 P00507 (/IDA)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
1 P05202 (/ISO)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P00508 (/IDA)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P00507 (/IMP)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P05202 (/ISO)
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P05202 (/IDA)
Aspartate catabolic process GO:0006533
The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P00505 (/IDA)
Aspartate catabolic process GO:0006533
The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P05202 (/ISO)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
1 P00508 (/IDA)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 P00507 (/IEP)
Lactation GO:0007595
The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
1 P00507 (/IEP)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
1 P00505 (/TAS)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 P00507 (/IEP)
Fatty acid transport GO:0015908
The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 P00505 (/IEP)
Fatty acid transport GO:0015908
The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 P00507 (/TAS)
4-hydroxyproline catabolic process GO:0019470
The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline.
1 P00505 (/TAS)
Glutamate catabolic process to aspartate GO:0019550
The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate.
1 P05202 (/IDA)
Glutamate catabolic process to 2-oxoglutarate GO:0019551
The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.
1 P05202 (/ISO)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P00507 (/IEP)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 P00507 (/IEP)
Dicarboxylic acid metabolic process GO:0043648
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
1 P00507 (/IDA)
Dicarboxylic acid metabolic process GO:0043648
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
1 P05202 (/ISO)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P00505 (/IDA)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P05202 (/ISO)
Glyoxylate metabolic process GO:0046487
The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
1 P00505 (/TAS)

There are 24 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
16 P00505 (/ISS) P00506 (/ISS) P00506 (/ISS) P00507 (/ISS) P05202 (/ISS) P08907 (/ISS) P12344 (/ISS) P12345 (/ISS) Q28F67 (/ISS) Q4R559 (/ISS)
(6 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P00505 (/IDA) P00507 (/IDA) P00508 (/IDA) P05202 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 P00506 (/ISS) P00506 (/ISS) P12344 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 P00505 (/TAS) P00507 (/TAS) P00508 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P00505 (/HDA) P05202 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P00505 (/IDA) P00507 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P05202 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P05202 (/HDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P00507 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P05202 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P05202 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P00507 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P05202 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P12344 (/ISS)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P00507 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P05202 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P00507 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P05202 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 P00507 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 P05202 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P00507 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P05202 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P05202 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P00505 (/HDA)
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