The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 17: Glutamate decarboxylase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate decarboxylase activity GO:0004351
Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
137 P69908 (/IDA) P69908 (/IDA) P69908 (/IDA) P69908 (/IDA) P69908 (/IDA) P69908 (/IDA) P69908 (/IDA) P69908 (/IDA) P69908 (/IDA) P69908 (/IDA)
(127 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
129 P69908 (/IPI) P69908 (/IPI) P69908 (/IPI) P69908 (/IPI) P69908 (/IPI) P69908 (/IPI) P69908 (/IPI) P69908 (/IPI) P69908 (/IPI) P69908 (/IPI)
(119 more)
Glutamate decarboxylase activity GO:0004351
Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
8 Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP)
Glutamate decarboxylase activity GO:0004351
Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
2 Q54IJ3 (/ISS) Q54VQ5 (/ISS)
Glutamate decarboxylase activity GO:0004351
Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
2 Q5B1Y3 (/RCA) Q5B1Y3 (/RCA)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular pH elevation GO:0051454
Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.
129 P69908 (/IMP) P69908 (/IMP) P69908 (/IMP) P69908 (/IMP) P69908 (/IMP) P69908 (/IMP) P69908 (/IMP) P69908 (/IMP) P69908 (/IMP) P69908 (/IMP)
(119 more)
Glutamate catabolic process GO:0006538
The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
8 Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
8 Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP) Q04792 (/IMP)
Glutamate catabolic process GO:0006538
The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
6 Q2TY91 (/IDA) Q2TY91 (/IDA) Q2TY91 (/IDA) Q2TY91 (/IDA) Q2TY91 (/IDA) Q2TY91 (/IDA)
Gamma-aminobutyric acid metabolic process GO:0009448
The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.
6 Q2TY91 (/IMP) Q2TY91 (/IMP) Q2TY91 (/IMP) Q2TY91 (/IMP) Q2TY91 (/IMP) Q2TY91 (/IMP)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
2 Q5E5Y7 (/IDA) Q5E5Y7 (/IDA)
Glutamate catabolic process GO:0006538
The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
2 Q54IJ3 (/ISS) Q54VQ5 (/ISS)
Glutamate decarboxylation to succinate GO:0006540
The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.
2 Q5B1Y3 (/RCA) Q5B1Y3 (/RCA)
Aggregation involved in sorocarp development GO:0031152
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
1 Q54IJ3 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
129 P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA)
(119 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
129 P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA) P69908 (/HDA)
(119 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q04792 (/HDA) Q04792 (/HDA) Q04792 (/HDA) Q04792 (/HDA) Q04792 (/HDA) Q04792 (/HDA) Q04792 (/HDA) Q04792 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q54IJ3 (/IDA) Q54VQ5 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...