The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase C15, pyroglutamyl peptidase I-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Pyrrolidone-carboxylate peptidase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyroglutamyl-peptidase I. [EC: 3.4.19.3]
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • Inhibited by thiol-blocking reagents.
  • Belongs to peptidase family C15.
  • Formerly EC 3.4.11.8.
113 A0A0E3K8X2 A0A0E3K8X2 A0A0E3K8X2 A0A157T226 A0A157T226 A0A157T226 A0A157T226 A0A157T226 A0A157T226 A0A157T226
(103 more...)