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CATH Superfamily 3.40.630.10

Zn peptidases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Zn peptidases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Carboxypeptidase B

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carboxypeptidase A. [EC: 3.4.17.1]
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
  • Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells and skeletal muscle.
  • Belongs to peptidase family M14.
  • Formerly EC 3.4.2.1 and EC 3.4.12.2.
 11 P00730 P00731 P09954 P15085 P15088 P15089 P15089 P21961 Q542E3 Q542E3
(1 more...)
Carboxypeptidase B. [EC: 3.4.17.2]
Preferential release of a C-terminal lysine or arginine amino acid.
  • Isolated from cattle, pig and dogfish pancreas, and other sources, including skin fibroblasts and adrenal medulla.
  • Belongs to peptidase family M14.
  • Formerly EC 3.4.2.2 and EC 3.4.12.3.
 8 B1PZ69 B1PZ69 P00732 P00732 P09955 P15086 P19223 P55261
Carboxypeptidase U. [EC: 3.4.17.20]
Release of C-terminal Arg and Lys from a polypeptide.
  • Pro-carboxypeptidase U in plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
  • Activity similar to that of the more stable lysine carboxypeptidase, except no preference is shown for Lys over Arg.
  • Belongs to peptidase family M14.
 7 L8IGL2 L8IGL2 Q2KIG3 Q2KIG3 Q96IY4 Q9EQV9 Q9JHH6
Carboxypeptidase A2. [EC: 3.4.17.15]
Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues.
  • Isolated from rat pancreas but not present in cattle pancreas.
  • Belongs to peptidase family M14.
 3 P19222 P48052 Q504N0
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