The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 7: NAD/NADP-dependent betaine aldehyde dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phenylacetaldehyde dehydrogenase activity GO:0008957
Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+.
51 O06837 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA)
(41 more)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
50 P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA)
(40 more)
4-hydroxyphenylacetaldehyde dehydrogenase activity GO:0047106
Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate.
50 P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA)
(40 more)
Betaine-aldehyde dehydrogenase activity GO:0008802
Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.
34 O24174 (/IDA) O24174 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA)
(24 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
21 P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA)
(11 more)
Betaine-aldehyde dehydrogenase activity GO:0008802
Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.
15 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) Q88AE9 (/ISS) Q88AE9 (/ISS) Q88AE9 (/ISS) Q88AE9 (/ISS)
(5 more)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
9 A0A0B4K6I6 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) Q9VB96 (/ISS)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
2 Q9STS1 (/IDA) Q9STS1 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
1 O14293 (/ISO)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
1 O14293 (/ISO)
Phenylacetaldehyde dehydrogenase activity GO:0008957
Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+.
1 Q5LLB4 (/ISS)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
71 P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA)
(61 more)
NAD biosynthetic process GO:0009435
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
50 P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA)
(40 more)
Phenylethylamine catabolic process GO:0019607
The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds.
50 P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA)
(40 more)
4-nitrophenol catabolic process GO:0046196
The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion.
50 P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA) P80668 (/IDA)
(40 more)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
21 P17445 (/IEP) P17445 (/IEP) P17445 (/IEP) P17445 (/IEP) P17445 (/IEP) P17445 (/IEP) P17445 (/IEP) P17445 (/IEP) P17445 (/IEP) P17445 (/IEP)
(11 more)
Response to X-ray GO:0010165
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
21 P17445 (/IMP) P17445 (/IMP) P17445 (/IMP) P17445 (/IMP) P17445 (/IMP) P17445 (/IMP) P17445 (/IMP) P17445 (/IMP) P17445 (/IMP) P17445 (/IMP)
(11 more)
Glycine betaine biosynthetic process from choline GO:0019285
The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline.
21 P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA)
(11 more)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
16 A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) A0A1Q4LYX8 (/ISS) Q88AE9 (/ISS) Q88AE9 (/ISS) Q88AE9 (/ISS)
(6 more)
Isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway GO:0019288
The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
9 O33340 (/IMP) O33340 (/IMP) O33340 (/IMP) O33340 (/IMP) O33340 (/IMP) O33340 (/IMP) O33340 (/IMP) O33340 (/IMP) O33340 (/IMP)
Cellular response to anoxia GO:0071454
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.
8 O24174 (/IDA) O24174 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA)
Cellular response to anoxia GO:0071454
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.
6 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 A0A0B4K6I6 (/ISS) Q9VB96 (/ISS)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 Q9STS1 (/IEP) Q9STS1 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 Q9S795 (/IMP) Q9S795 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 Q9S795 (/IMP) Q9S795 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 Q9STS1 (/IEP) Q9STS1 (/IEP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 Q9STS1 (/IDA) Q9STS1 (/IDA)
Ethanol catabolic process GO:0006068
The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
1 O14293 (/ISS)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
1 O14293 (/ISO)
NADPH regeneration GO:0006740
A metabolic process that generates a pool of NADPH by the reduction of NADP+.
1 O14293 (/ISO)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
1 O14293 (/ISO)
Phenylethylamine catabolic process GO:0019607
The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds.
1 Q5LLB4 (/ISS)
Styrene catabolic process GO:0042207
The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene.
1 O06837 (/IDA)
Cellular detoxification of nitrogen compound GO:0070458
Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
1 O59808 (/IC)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
23 P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA) P17445 (/IDA)
(13 more)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
12 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) Q84LK3 (/ISS) Q84LK3 (/ISS) Q84LK3 (/ISS) Q84LK3 (/ISS)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 O33340 (/HDA) O33340 (/HDA) O33340 (/HDA) O33340 (/HDA) O33340 (/HDA) O33340 (/HDA) O33340 (/HDA) O33340 (/HDA) O33340 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
4 O24174 (/IDA) O24174 (/IDA) Q9STS1 (/IDA) Q9STS1 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 A0A0B4K6I6 (/ISS) O14293 (/ISS) Q9VB96 (/ISS)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
2 Q9S795 (/IDA) Q9S795 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O14293 (/HDA) O59808 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O14293 (/HDA) O59808 (/HDA)
Leucoplast GO:0009516
A colorless plastid involved in the synthesis of monoterpenes.
2 Q9S795 (/IDA) Q9S795 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O14293 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O14293 (/HDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...