The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: 4-trimethylaminobutyraldehyde dehydrogenase isofor...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
4-trimethylammoniobutyraldehyde dehydrogenase activity GO:0047105
Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.
7 Q19A30 (/ISS) Q2KJH9 (/ISS) Q5R8A4 (/ISS) Q7ZVB2 (/ISS) Q7ZVB2 (/ISS) Q802W2 (/ISS) Q9JLJ2 (/ISS)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
2 P49189 (/IDA) Q9JLJ3 (/IDA)
Aminobutyraldehyde dehydrogenase activity GO:0019145
Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+.
2 P49189 (/IDA) Q9JLJ3 (/IDA)
4-trimethylammoniobutyraldehyde dehydrogenase activity GO:0047105
Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.
2 P49189 (/IDA) Q9JLJ3 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
1 Q9JLJ2 (/ISO)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
1 Q2KJH9 (/ISS)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620
Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
1 Q9JLJ2 (/IDA)
Aminobutyraldehyde dehydrogenase activity GO:0019145
Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+.
1 Q9JLJ2 (/ISO)
Aminobutyraldehyde dehydrogenase activity GO:0019145
Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+.
1 Q2KJH9 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9JLJ3 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9JLJ2 (/ISO)
Amine binding GO:0043176
Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
1 Q9JLJ3 (/IDA)
Amine binding GO:0043176
Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
1 Q9JLJ2 (/ISO)
4-trimethylammoniobutyraldehyde dehydrogenase activity GO:0047105
Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.
1 Q9JLJ2 (/ISO)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 Q9JLJ3 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 Q9JLJ2 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
8 Q19A30 (/ISS) Q2KJH9 (/ISS) Q5R8A4 (/ISS) Q7ZVB2 (/ISS) Q7ZVB2 (/ISS) Q802W2 (/ISS) Q9JLJ2 (/ISS) Q9JLJ3 (/ISS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
8 Q19A30 (/ISS) Q2KJH9 (/ISS) Q5R8A4 (/ISS) Q7ZVB2 (/ISS) Q7ZVB2 (/ISS) Q802W2 (/ISS) Q9JLJ2 (/ISS) Q9JLJ3 (/ISS)
Carnitine biosynthetic process GO:0045329
The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
2 P49189 (/TAS) Q9JLJ3 (/TAS)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 Q9JLJ3 (/IEP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 Q9JLJ3 (/IEP)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
1 P49189 (/IDA)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
1 Q9JLJ2 (/ISO)
Carnitine metabolic process GO:0009437
The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
1 Q9JLJ2 (/IDA)
Neurotransmitter biosynthetic process GO:0042136
The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
1 P49189 (/IDA)
Neurotransmitter biosynthetic process GO:0042136
The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
1 Q9JLJ2 (/ISO)
Neurotransmitter biosynthetic process GO:0042136
The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
1 Q2KJH9 (/ISS)
Hormone metabolic process GO:0042445
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
1 P49189 (/TAS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P49189 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P49189 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q9JLJ2 (/ISO)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q2KJH9 (/ISS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9JLJ2 (/IDA) Q9JLJ3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P49189 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9JLJ2 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9JLJ2 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9JLJ3 (/NAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P49189 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P49189 (/HDA)
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