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CATH Superfamily 3.40.605.10

Aldehyde Dehydrogenase; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: NAD-dependent succinate-semialdehyde dehydrogenase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]
Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H.
    		 432 A0A024L3N1 A0A024L3N1 A0A024L3N1 A0A024L3N1 A0A024L3N1 A0A024L3N1 A0A024L3N1 A0A024L3N1 A0A024L3N1 A0A024L3N1
    (422 more...)
    Succinate-semialdehyde dehydrogenase (NADP(+)). [EC: 1.2.1.79]
    Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH.
    • This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
    • It is similar to EC 1.2.1.24 and EC 1.2.1.16 but is specific for NADP(+).
    • The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).
    		 95 A0A0E8WS10 A0A0E8WS10 A0A0E8WS10 A0A0E8WS10 A0A0E8WS10 A0A0E8WS10 A0A0E8WS10 A0A0E8WS10 A0A0E8WS10 A0A0H3L4Y9
    (85 more...)
    Aldehyde dehydrogenase (NADP(+)). [EC: 1.2.1.4]
    An aldehyde + NADP(+) + H(2)O = a carboxylate + NADPH.
      		 1 Q8GAK7
      Vanillin dehydrogenase. [EC: 1.2.1.67]
      Vanillin + NAD(+) + H(2)O = vanillate + NADH.
        		 1 O05619
        Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
        An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
        • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
        • Formerly EC 1.1.1.70.
        		 1 Q8GAK7
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