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CATH Superfamily 3.40.605.10

Aldehyde Dehydrogenase; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Aldehyde dehydrogenase 1

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]
4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH.
  • The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates.
  • The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54).
  • As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate.
  • Formerly EC 1.5.1.35.
 893 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2 A0A027ZLX2
(883 more...)
Aldehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.5]
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
    		 552 A0A037YAA6 A0A037YAA6 A0A037YAA6 A0A037YAA6 A0A037YAA6 A0A037YAA6 A0A037YAA6 A0A037YAA6 A0A037YAA6 A0A037YAA6
    (542 more...)
    Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
    An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
    • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
    • Formerly EC 1.1.1.70.
    		 128 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A0H3L9K4
    (118 more...)
    Aldehyde dehydrogenase (NADP(+)). [EC: 1.2.1.4]
    An aldehyde + NADP(+) + H(2)O = a carboxylate + NADPH.
      		 81 A0A0L8VFR9 A0A0L8VFR9 A0A0L8VFR9 A0A0L8VFR9 A0A0L8VFR9 A0A0L8VFR9 A0A0L8VFR9 A0A0L8VFR9 A0A0L8VFR9 A6ZWI7
      (71 more...)
      Retinal dehydrogenase. [EC: 1.2.1.36]
      Retinal + NAD(+) + H(2)O = retinoate + NADH.
      • Acts on both the 11-trans- and 13-cis-forms of retinal.
      		 38 A0A024RC95 A0A024RC95 A0A1U7QDB4 A0A1U7QDB4 A0A226PKF6 A0A226PKF6 G2HJM2 G2HJM2 G2HJM2 O93344
      (28 more...)
      Aminomuconate-semialdehyde dehydrogenase. [EC: 1.2.1.32]
      2-aminomuconate 6-semialdehyde + NAD(+) + H(2)O = 2-aminomuconate + NADH.
      • Also acts on 2-hydroxymuconate semialdehyde.
      		 7 A9YD19 A9YD19 Q0P5F9 Q66I21 Q66I21 Q8BH00 Q9H2A2
      Fluoroacetaldehyde dehydrogenase. [EC: 1.2.1.69]
      Fluoroacetaldehyde + NAD(+) + H(2)O = fluoroacetate + NADH.
      • The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
      		 1 F8JX40
      Long-chain-aldehyde dehydrogenase. [EC: 1.2.1.48]
      A long-chain aldehyde + NAD(+) + H(2)O = a long-chain acid anion + NADH.
      • The best substrate is dodecylaldehyde.
      		 1 Q9FDS1
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