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CATH Superfamily 3.40.50.80

Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: Probable ferric reductase transmembrane component

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ferric-chelate reductase (NADPH). [EC: 1.16.1.9]
2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH.
  • The enzyme, which is widespread among bacteria, catalyzes the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron.
  • The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolyzed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine.
  • Cf. EC 1.16.1.7 and EC 1.16.1.10.
 1 Q5A446
Ferric-chelate reductase (NADH). [EC: 1.16.1.7]
2 Fe(II)-siderophore + NAD(+) + H(+) = 2 Fe(III)-siderophore + NADH.
  • The enzyme catalyzes the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron.
  • The plant enzyme is involved in the transport of iron across plant plasma membranes.
  • The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate.
  • Cf. EC 1.16.1.9 and EC 1.16.1.10.
  • Formerly EC 1.6.99.13.
 1 P78588