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CATH Superfamily 3.40.50.80

Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: NADPH--cytochrome P450 reductase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Assimilatory sulfite reductase (NADPH). [EC: 1.8.1.2]
H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH.
  • The enzyme, which catalyzes the six-electron reduction of sulfite to sulfide, is involved in sulfate assimilation in bacteria and yeast.
  • Different from EC 1.8.99.5, which is involved in prokaryotic sulfur- based energy metabolism.
  • Formerly EC 1.8.99.1.
 710 A0A028A5D6 A0A028A5D6 A0A028A5D6 A0A028A5D6 A0A028A5D6 A0A028A5D6 A0A028A5D6 A0A028A5D6 A0A028A5D6 A0A028A5D6
(700 more...)
NADPH--hemoprotein reductase. [EC: 1.6.2.4]
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
  • This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN.
  • It also reduces cytochrome b5 and cytochrome c.
  • The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
 66 A0A0J5T025 A0A0J5T025 A0A0J5T025 A0A0J5T025 A0A178USJ1 A0A178USJ1 A0A178UWR2 A0A178UWR2 A0A229W772 A0A229W772
(56 more...)