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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Fatty oxidation complex, alpha subunit

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Enoyl-CoA hydratase. [EC: 4.2.1.17]
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.
  • Acts in the reverse direction.
  • With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).
 2291 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
(2281 more...)
3-hydroxybutyryl-CoA epimerase. [EC: 5.1.2.3]
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.
    		 2281 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
    (2271 more...)
    3-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.35]
    (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
    • Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.
    • Some enzymes act, more slowly, with NADP(+).
    • Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
    		 2281 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
    (2271 more...)
    Delta(3)-Delta(2)-enoyl-CoA isomerase. [EC: 5.3.3.8]
    (1) A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA. (2) A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
    • The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position.
    • Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C(3), which cannot be processed further by the regular enzymes of the beta- oxidation system.
    • This enzyme isomerizes the bond to a trans bond at position C(2), which can be processed further.
    • The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers.
    • The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
    		 1512 A0A029HEK6 A0A029HEK6 A0A029HEK6 A0A029IHZ1 A0A029IHZ1 A0A029IHZ1 A0A069QB72 A0A069QB72 A0A069QB72 A0A069QB72
    (1502 more...)
    3-hydroxybutyryl-CoA dehydrogenase. [EC: 1.1.1.157]
    (S)-3-hydroxybutanoyl-CoA + NADP(+) = 3-acetoacetyl-CoA + NADPH.
      		 81 A0A045HU66 A0A045HU66 A0A045HU66 A0A045HU66 A0A045HU66 A0A045HU66 A0A045HU66 A0A045HU66 A0A045HU66 A0A0H3L5P5
      (71 more...)
      Long-chain-3-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.211]
      A long-chain (S)-3-hydroxyacyl-CoA + NAD(+) = a long-chain 3-oxoacyl-CoA + NADH.
      • This enzyme was purified from the mitochondrial inner membrane.
      • The enzyme has a preference for long-chain substrates, and activity with C(16) substrates was 6- to 15-fold higher than with C(4) substrates (cf. EC 1.1.1.35).
      		 10 A0A480V8E1 A0A480V8E1 E9KL44 E9KL44 P40939 P40939 Q29554 Q29554 Q64428 Q8BMS1
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