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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 879: Uronate dehydrogenase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Uronate dehydrogenase. [EC: 1.1.1.203]
(1) Beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + NADH. (2) Beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + NADH.
  • The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate.
  • The enzyme can only accept the beta anomeric form of the substrate.
  • The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyze spontaneously at a substantial rate.
  • Formerly EC 1.2.1.35.
 1 Q7CRQ0