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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 85: Dihydroflavonol reductase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Flavanone 4-reductase. [EC: 1.1.1.234]
(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH.
  • Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol.
 14 B1GV15 B1GV15 M9T025 M9T025 P14720 P14720 P51102 P51102 P51107 P51108
(4 more...)
Dihydroflavanol 4-reductase. [EC: 1.1.1.219]
A (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + NADPH.
  • This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)- dihydromyricetin, although some enzymes may act only on a subset of these compounds.
  • Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4- diol.
  • NAD(+) can act instead of NADP(+), but more slowly.
 14 B1GV15 B1GV15 M9T025 M9T025 P14720 P14720 P51102 P51102 P51107 P51108
(4 more...)
Anthocyanidin reductase ((2S)-flavan-3-ol-forming). [EC: 1.3.1.112]
(1) A (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH. (2) A (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 NADPH.
  • The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway.
  • It catalyzes the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols.
  • The enzyme catalyzes sequential hydride transfers to C-2 and C-4, respectively.
  • Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers.
  • Cf. EC 1.3.1.77.
 3 D7U6G6 Q5FB34 Q7PCC4
Anthocyanidin reductase ((2R,3R)-flavan-3-ol-forming). [EC: 1.3.1.77]
A (2R,3R)-flavan-3-ol + 2 NAD(P)(+) = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H.
  • The enzyme participates in the flavonoid biosynthesis pathway found in plants.
  • It catalyzes the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins.
  • While the enzyme from the legume Medicago truncatula can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana uses only NADPH.
  • Also, while the substrate preference of the M.truncatula is cyanidin>pelargonidin>delphinidin, the reverse preference is found with the Arabidopsis enzyme.
  • Cf. EC 1.3.1.112.
 1 Q9SEV0