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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 84: Short-chain dehydrogenase reductase

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. [EC: 1.1.1.53]
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
  • The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
 99 A0A045JKA8 A0A045JKA8 A0A045JKA8 A0A045JKA8 A0A045JKA8 A0A045JKA8 A0A045JKA8 A0A045JKA8 A0A045JKA8 A0A0E7Z222
(89 more...)
Carbonyl reductase (NADPH). [EC: 1.1.1.184]
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
 14 A0A2J8TRK8 A0A2J8TRK8 A0A480VYS5 A0A480VYS5 G5EGA6 Q5RCF8 Q5RCF8 Q8SPU8 Q8VID1 Q8WNV7
(4 more...)
Secoisolariciresinol dehydrogenase. [EC: 1.1.1.331]
(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 NADH.
  • Isolated from the plants Forsythia intermedia and Podophyllum peltatum.
  • An intermediate lactol is detected in vitro.
 10 A0A0M4J2R3 A0A0M4J2R3 A0A0M4J2R3 Q1ZZ69 Q1ZZ69 Q1ZZ69 Q94KL7 Q94KL8 Q94KL8 Q94KL8
Tropinone reductase II. [EC: 1.1.1.236]
Pseudotropine + NADP(+) = tropinone + NADPH.
  • Represents, along with EC 1.1.1.206, a branch point in tropane alkaloid metabolism.
  • Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines.
  • Both enzymes are always found together in any given tropane-alkaloid- producing species, have a common substrate, tropinone, and are strictly stereospecific.
 2 P50163 P50164
Isopiperitenol dehydrogenase. [EC: 1.1.1.223]
(-)-trans-isopiperitenol + NAD(+) = (-)-isopiperitenone + NADH.
  • Acts on (-)-trans-isopiperitenol, (+)-trans-piperitenol and (+)- trans-pulegol.
  • Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves.
 1 Q5C9I9
Xanthoxin dehydrogenase. [EC: 1.1.1.288]
Xanthoxin + NAD(+) = abscisic aldehyde + NADH.
  • NADP(+) cannot replace NAD(+) and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate.
  • Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14, EC 1.13.11.51 and EC 1.14.13.93.
 1 Q9C826
Carveol dehydrogenase. [EC: 1.1.1.243]
(-)-trans-carveol + NADP(+) = (-)-carvone + NADPH.
    		 1 Q5C9I9