The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

NAD(P)-binding Rossmann-like Domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 808: Iridoid synthase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Delta(4)-3-oxosteroid 5-beta-reductase. [EC:]
(1) 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH. (2) 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone + NADPH.
  • The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent.
  • The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
4 A0A178V158 A0A178V158 Q9STX2 Q9STX2
Iridoid synthase. [EC:]
(6E)-8-oxogeranial + NAD(P)H = cis-trans-nepetalactol + NAD(P)(+).
  • Isolated from the plant Catharanthus roseus.
  • The reaction may involve cyclization via a Diels-Alder or Michael reaction.
  • Iridoids are involved in the biosynthesis of many indole alkaloids.
  • The cyclic hemiacetal is readily hydrolyzed to the corresponding dial.
3 A0A1C9CX56 A0A1C9CX66 K7WDL7