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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 536: Sorbitol dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Galactitol 2-dehydrogenase. [EC: 1.1.1.16]
Galactitol + NAD(+) = D-tagatose + NADH.
  • Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars.
  • The enzyme from Agrobacterium rubrum C58 is part of D-altritol and galactitol degradation pathways.
 10 A0A083ZL67 A0A083ZL67 A0A083ZL67 A0A3G2CUN4 A0A3G2CUN4 A0A3G2CUN4 A9CES4 A9CES4 A9CES4 Q59787
L-iditol 2-dehydrogenase. [EC: 1.1.1.14]
L-iditol + NAD(+) = L-sorbose + NADH.
  • This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals.
  • It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol.
  • Enzymes from different organisms or tissues display different substrate specificity.
  • The enzyme is specific to NAD(+) and can not use NADP(+).
 1 Q59787
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