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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 484: Pentafunctional AROM polypeptide

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Shikimate kinase. [EC: 2.7.1.71]
ATP + shikimate = ADP + shikimate 3-phosphate.
    		 12 A6ZY89 B3LGE9 B9WFG1 C7GIN5 C8Z543 P08566 P0CM22 P0CM22 P0CM23 P0CM23
    (2 more...)
    3-dehydroquinate synthase. [EC: 4.2.3.4]
    3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.
    • The hydrogen atoms on C-7 of the substrate are retained on C-2 of the products.
    • Formerly EC 4.6.1.3.
    		 12 A6ZY89 B3LGE9 B9WFG1 C7GIN5 C8Z543 P08566 P0CM22 P0CM22 P0CM23 P0CM23
    (2 more...)
    3-phosphoshikimate 1-carboxyvinyltransferase. [EC: 2.5.1.19]
    Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate.
      		 12 A6ZY89 B3LGE9 B9WFG1 C7GIN5 C8Z543 P08566 P0CM22 P0CM22 P0CM23 P0CM23
      (2 more...)
      Shikimate dehydrogenase. [EC: 1.1.1.25]
      Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
      • NAD(+) cannot replace NADP(+).
      • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
      		 12 A6ZY89 B3LGE9 B9WFG1 C7GIN5 C8Z543 P08566 P0CM22 P0CM22 P0CM23 P0CM23
      (2 more...)
      3-dehydroquinate dehydratase. [EC: 4.2.1.10]
      3-dehydroquinate = 3-dehydroshikimate + H(2)O.
        		 12 A6ZY89 B3LGE9 B9WFG1 C7GIN5 C8Z543 P08566 P0CM22 P0CM22 P0CM23 P0CM23
        (2 more...)