The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
113 P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA)
(103 more)
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity GO:0030604
Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH.
113 P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA)
(103 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
104 P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA) P45568 (/IDA)
(94 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
9 P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
9 P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
9 P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA)
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
8 Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway GO:0019288
The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
104 P45568 (/IMP) P45568 (/IMP) P45568 (/IMP) P45568 (/IMP) P45568 (/IMP) P45568 (/IMP) P45568 (/IMP) P45568 (/IMP) P45568 (/IMP) P45568 (/IMP)
(94 more)
Terpenoid biosynthetic process, mevalonate-independent GO:0051483
The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate.
9 P9WNS1 (/IMP) P9WNS1 (/IMP) P9WNS1 (/IMP) P9WNS1 (/IMP) P9WNS1 (/IMP) P9WNS1 (/IMP) P9WNS1 (/IMP) P9WNS1 (/IMP) P9WNS1 (/IMP)
Isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process GO:0051484
The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
9 P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA) P9WNS1 (/IDA)
Isoprenoid biosynthetic process GO:0008299
The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
8 Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS) Q9KPV8 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apicoplast GO:0020011
The plastid organelle found in apicomplexans.
13 Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA) Q8IKG4 (/IDA)
(3 more)
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