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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 436: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. [EC: 2.4.99.20]
NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.
  • This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 3.2.2.6.
 16 F6QEE7 F6QEE7 F6QEE7 G7P5B0 G7P5B0 G7P5B0 P28907 P56528 P56528 Q4FJL8
(6 more...)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. [EC: 3.2.2.6]
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
  • This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 2.4.99.20.
  • It is also able to act on beta-nicotinamide D-ribonucleotide.
  • Cf. EC 3.2.2.5.
 16 F6QEE7 F6QEE7 F6QEE7 G7P5B0 G7P5B0 G7P5B0 P28907 P56528 P56528 Q4FJL8
(6 more...)
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